项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:805747

Chemical Name: (T-4)-Tetrakis[(phosphinidyne-kappaP)tris(methanol)]gold(+1) chloride; Tetrakis[tris(hydroxymethyl)phosphine]gold(I) chloride
CAS No. 313695-66-8, 193076-00-5 (sodium salt)
项目整合开发...
参考文献标题:Gold-containing chemotherapeutic agents
文献作者:Kamei,H.; Katti,K.V.; Volkert,W.A.; Hoffman,T.J.(University of Missouri)
参考来源:WO 0078306

新产品编号:769361

Chemical Name: N,N'-(1,3-Propylene)bis(oxy)bis(naphthalen-7,1-diyl)bis(1,2-ethylene)bis(acetamide)
CAS No. 296280-56-3
项目整合开发状态: Biological Testing
项目研究机构: Servier (Originator)
合成路线:Demeth...
参考文献标题:Substd.dimeric cpds.,process for their preparation and pharmaceutical compsns.thereof
文献作者:Guillaumet,G.; Renard,P.; Lesieur,D.; Yous,S.; Descamps-Francois,C.; Lefoulon,F.; Viaud,M.-C.; Delagrange,P.; Bennejean,C.(ADIR et Cie.)
参考来源:EP 1038863; FR 2791344; JP 2000319242; US 2002035114; US 6319930; US 6635650

新产品编号:911741

Chemical Name: (+)-4(R)-[2-(1,1-Diphenylmethoxy)ethyl]-1-(4-fluorobenzyl)piperidin-3(R)-ol
CAS No. 383362-75-2 (stereoisomer)
项目整合开发状态: Preclinical
项目研究机构: Wayne State University (Originator)...
参考文献标题:N- and O-substd.4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith
文献作者:Dutta,A.K.(Wayne State University)
参考来源:WO 0198266

新产品编号:785181

Chemical Name: 3-Cyclobutyl-2(R)-[3(S)-(3-fluorophenyl)-4(S)-[4-[N-propyl-N-[5-(trifluoromethyl)pyrimidin-2-yl]amino]piperidin-1-ylmethyl]pyrrolidin-1-yl]propionic acid
CAS No. 301223-53-0
项目整合开...
参考文献标题:Pyrrolidine modulators of chemokine receptor activity
文献作者:Mills,S.G.; Kim,D.; Hale,J.; MacCoss,M.; Berk,S.; Chapman,K.; Lynch,C.; Caldwell,C.; Willoughby,C.; Kim,R.M.(Merck & Co.,Inc.)
参考来源:US 6498161; WO 0059498

新产品编号:899085

Chemical Name: 2-[3-(Dimethylamino)-2,3-dihydro-1H-inden-5-yl]-7-methoxy-6-(5-oxazolyl)quinolin-4(1H)-one
CAS No. 371251-98-8 ((R)-isomer), 371251-99-9 ((S)-isomer), 371249-88-6 (undefined isomer)<...
参考文献标题:Heterocycles that are inhibitors of IMPDH enzyme
文献作者:Pitts,W.J.; Iwanowicz,E.J.; Dhar,T.G.M.; Gu,H.H.; Watterson,S.H.(Bristol-Myers Squibb Co.)
参考来源:EP 1276739; JP 2003531205; WO 0181340

新产品编号:949709

Chemical Name: 1-[4-[4-(Pyrrolidin-1-ylmethyl)benzyloxy]phenyl]ethanone oxalate
CAS No. 462115-49-7, 462115-48-6 (free base)
项目整合开发状态: Preclinical
项目研究机构: Bioprojet (Originator)
合成路线:Conde...
参考文献标题:Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications
文献作者:Schwartz,J.-C.; Lecomte,J.-M.; Arrang,J.-M.; Garbarg,M.; Ganellin,C.R.; Stark,H.; Ligneau,X.; Schunack,W.G.; Leurquin,F.; Sigurd,E.(Societe Civile Bioprojet)
参考来源:EP 1100503; EP 1428820; WO 0006254

新产品编号:957619

Chemical Name: N-(2,4-Dichlorobenzoyl)-N-(3-nitrobenzyl)-L-phenylalanine
CAS No. 478294-73-4
项目整合开发状态: Biological Testing
项目研究机构: Shire BioChem (Originator)
合成路线:Acylation of L-phenylalani...
参考文献标题:Cpds.and methods for the treatment or prevention of flavivirus infections
文献作者:Pereira,O.Z.; Wang,W.; Siddiqui,M.A.; B閐ard,J.; Nguyen Ba,N.; Chan,C.K.L.; Das,S.K.; Shuttleworth,S.(Shire BioChem Inc.)
参考来源:US 2003229053; WO 02100846

SPI-376, NEO-376

Chemical Name: 1-[2-[4-(3-Chlorophenyl)piperazin-1-yl]ethyl]-4,5,6,7-tetrahydro-1H-indol-4-one
CAS No. 496921-73-4, 496921-74-5 (oxalate)
项目整合开发状态: Preclinical
项目研究机构: Spectrum Pharmaceutical...
参考文献标题:Tetrahydroindolone and purine derivs.linked to arylpiperazines
文献作者:Foreman,M.M.; Helton,D.R.; Glasky,A.J.; Fick,D.B.(Spectrum Pharmaceuticals,Inc.)
参考来源:WO 0311396

NF-115

Chemical Name: Octyl 2-acetamido-2-deoxy-6-O-[3-hydroxy-2,2-bis(hydroxymethyl)propyl]-alpha-D-glucopyranoside
CAS No. 368870-53-5
项目整合开发状态: Preclinical
项目研究机构: CSIC (Originator), Hospital Uni...
参考文献标题:Glycosides of N-acetyl-6-O-[2,2,-bis(hydroxymethyl)-3-hydroxypropyl]-D-glucosamine,method for the obtention thereof and their uses in the treatment of brain tumors
文献作者:Nieto Sampedro,M.; Bernabe Pajares,M.; Fernandez-Mayoralas Alvarez,A.; Vaquero Crespo,J.; Zurita Castillo,M.(CSIC (Consejo Superior de Investigaciones Cient韋icas); Hospital Universitario Puerta de Hierro)
参考来源:ES 2164013; WO 0179243

CP-8668

Chemical Name: N-Propylcarbamic acid (4aR,5R,6R,7R)-7-methoxy-1,3,4a,5-tetramethyl-2-oxo-2,4,4a,5,6,7-hexahydro-1H-benzo[f]indol-6-yl ester
CAS No. 209331-43-1
项目整合开发状态: Preclinical
项目研究机构: M...
参考文献标题:Novel tetrahydrobenzindolone derivs.
文献作者:Okonogi,T.; Kurihara,K.; Tabata,Y.; Shinei,R.; Kurata,Y.; Tanabe,K.(Meiji Seika Kaisha,Ltd.)
参考来源:EP 0947507; US 6077840; WO 9827059