SPI-376, NEO-376

Chemical Name: 1-[2-[4-(3-Chlorophenyl)piperazin-1-yl]ethyl]-4,5,6,7-tetrahydro-1H-indol-4-one
CAS No. 496921-73-4, 496921-74-5 (oxalate)
项目整合开发状态: Preclinical
项目研究机构: Spectrum Pharmaceuticals (Originator)
合成路线:N-(3-Chlorophenyl)piperazine (I) is alkylated with 1-bromo-2-chloroethane in the presence of NaOH in DMSO to afford the (2-chloroethyl)piperazine (II).Subsequent condensation of alkyl chloride (II) with 4,5,6,7-tetrahydro-1H-indol-4-one (III) gives rise to the title compound