项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

SK&F-88046

Chemical Name: N7-(3-Chlorophenyl)-N2-[[7-[[(3-chlorophenyl)amino]sulfonyl]-3,4-dihydro-2(1H)-isoquinolinyl]sulfonyl]-3,4-dihydro-2,7(1H)-isoquinolinedisulfonamide; N,N'-Bis[7-(3-chlorophenylaminosulf...
参考文献标题:N,N'-Bis[substituted-1,2,3,4-tetrahydroisoquinolino]disulfonylimides and antiallergic compositions and method of use
文献作者:Ali Fadia,E.(SmithKline Beecham Corp.)
参考来源:DD 158240; EP 0038177; US 4135935

Moxadolen, Lu-253

Chemical Name: 4-Oxa-5-(N-methylcarbamoyloxy)tricyclo[5,2,1,0(2,6)]dec-8-en-3-one; 3a,4,7,7a-Tetrahydro-3-[[(methylamino)carbonyl]oxy]-4,7-methanoisobenzofuran-1(3H)-one
CAS No. 56232-20-3
项目整合开...
参考文献标题:Carbamates and their use as pharmaceuticals
文献作者:Ammann,A.; et al.(BASF AG)
参考来源:US 3965119

Methosorbinil, M-79175, E-0722

Chemical Name: (S)-6-Fluoro-2(R)-methylspiro[chroman-4,4'-imidazolidine]-2',5'-dione; (S)-6-Fluoro-2,3-dihydro-2(R)-methylspiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione
CAS No. 82319-87-7 (r...
参考文献标题:Hydantoin derivatives,processes for preparing them and pharmaceutical compositions containing them
文献作者:Ueda,K.; Nomura,K.; Tanaka,S.; Nakai,N.(Eisai Co.,Ltd.)
参考来源:EP 0193855; JP 61197581

386/1634, FCE-386/1634

Chemical Name: 1,4-Diethyl-5-(N-isopropylthiocarbamoyl)-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine; 1,4-Diethyl-1,4,6,7-tetrahydro-N-(isopropyl)-5H-imidazo[4,5-c]pyridine-5-carbothioamide
CAS No. 706...
参考文献标题:4,5,6,7-Tetrahydroimidazo[4,5-c]pyridine derivatives
文献作者:Acari,G.; Bernardi,L.; Falconi,G.; Scarponi,U.(Pharmacia Corp.)
参考来源:BE 0871985; DE 2849572; FR 2433022; GB 2028798; JP 55024158; US 4223146

MDL-12330A, RMI-12330A

Chemical Name: N-(cis-2-Phenylcyclopentyl)azacyclotridecan-2-imine hydrochloride; cis-N-Azacyclotridec-2-ylidene-2-phenylcyclopentanamine hydrochloride
CAS No. 40297-09-4
项目整合开发状态: Preclinical 参考文献标题:RMI-12,330A
文献作者:Castar,J.; Hillier,K.
参考来源:Drugs Fut 1979,4(12),893

SK&F-88070

Chemical Name: [6R-[6alpha,7beta(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[[1-[2-(sulfoamino)ethyl]-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carbox...
参考文献标题:7-[2-Alkoxyimino-2-(aminothiazole)acetamido]-3-[1-sulfaminoalkyl)tetrazolthiomethyl]cephalosporins
文献作者:Berges,D.A.; Dunn,G.L.(SmithKline Beecham Corp.)
参考来源:EP 0043713; JP 57045189; US 4308267

Sch-24937

Chemical Name: 6-Bromo-5-chloro-2-[(methylsulfinyl)acetyl]-3-(2-pyridyl)indole; 1-[6-Bromo-5-chloro-3-(2-pyridinyl)-1H-indol-2-yl]-2-(methylsulfinyl)ethanone
CAS No. 75696-17-2
项目整合开发状态: Biologi...
参考文献标题:SCH-24,937
文献作者:Blancafort,P.; Castar,J.; Serradell,M.N.; Arrigoni-Martelli,E.
参考来源:Drugs Fut 1983,8(5),437

BRL-31660(free base), BRL-31660A

Chemical Name: N-[2-(2,4-Dimethyl-1-pyrrolidinyl)ethyl]-1-naphthalenesulfonamide (E)-2-butenedioate; 2,4-Dimethyl-1-[2-(1-naphthalenesulfonamido)ethyl]pyrrolidine fumarate
CAS No. 77709-56-9 (cis-f...
参考文献标题:Anti-arrythmic sulphonamide compositions
文献作者:Josic,L.
参考来源:EP 0021580; JP 56161373; US 4372955; US 4436908

REV-3164, RHC-3164

Chemical Name: 7-Chloro-5-propyl[1,2,4]triazolo[4,3-a]quinoxaline-1,4(2H,5H)-dione
CAS No. 80708-33-4
项目整合开发状态: Biological Testing
项目研究机构: Revlon (Originator)
合成路线:The cyctization of 4-chl...
参考文献标题:Triazaloquinoxalin-1,4-diones
文献作者:Brown,R.E.; Georgiev,V.; Kropp,P.; Loev,B.(USV Pharmaceutical Corp.)
参考来源:EP 0039920; JP 57004988; US 4400382