BRL-31660(free base), BRL-31660A
Chemical Name: N-[2-(2,4-Dimethyl-1-pyrrolidinyl)ethyl]-1-naphthalenesulfonamide (E)-2-butenedioate; 2,4-Dimethyl-1-[2-(1-naphthalenesulfonamido)ethyl]pyrrolidine fumarate
CAS No. 77709-56-9 (cis-free base), 77709-55-8 (free base)
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmithKline (Originator)
合成路线:By condensation of 2,4-dimethyl-1-(2-aminoethyl)pyrrolidine (I) with 1-naphtalenesulfonyl chloride (II) in refluxing benzene,followed by a treatment with fumaric acid (III) in absolute ethanol.
📌 参考资料/链接：
参考文献标题:Anti-arrythmic sulphonamide compositions
文献作者:Josic,L.
参考来源:EP 0021580; JP 56161373; US 4372955; US 4436908
📄 详细内容
合成路线:By condensation of 2,4-dimethyl-1-(2-aminoethyl)pyrrolidine (I) with 1-naphtalenesulfonyl chloride (II) in refluxing benzene,followed by a treatment with fumaric acid (III) in absolute ethanol.
参考文献标题:BRL-31660 A
文献作者:Castar,J.; Thorpe,P.
参考来源:Drugs Fut 1985,10(10),810