Moxadolen, Lu-253
Chemical Name: 4-Oxa-5-(N-methylcarbamoyloxy)tricyclo[5,2,1,0(2,6)]dec-8-en-3-one; 3a,4,7,7a-Tetrahydro-3-[[(methylamino)carbonyl]oxy]-4,7-methanoisobenzofuran-1(3H)-one
CAS No. 56232-20-3
项目整合开发状态: Preclinical
项目研究机构: Abbott (Originator)
合成路线:This compound can be obtained in two different ways:1) By reaction of 4-oxa-5-hydroxytricyclo[5.2.1.0(2,6)]dec-8-en-3-one (I) with methyl isocyanate (II) in refluxing THF.2) By a Diels-Alder reaction of cyclopentadiene (III) with 2-(N-methylcarbamoyloxy)-2,5-dihydrofuran-5 one (IV) in THF at 120 C in a pressure vessel.
📌 参考资料/链接：
参考文献标题:Carbamates and their use as pharmaceuticals
文献作者:Ammann,A.; et al.(BASF AG)
参考来源:US 3965119
📄 详细内容
合成路线:This compound can be obtained in two different ways:1) By reaction of 4-oxa-5-hydroxytricyclo[5.2.1.0(2,6)]dec-8-en-3-one (I) with methyl isocyanate (II) in refluxing THF.2) By a Diels-Alder reaction of cyclopentadiene (III) with 2-(N-methylcarbamoyloxy)-2,5-dihydrofuran-5 one (IV) in THF at 120 C in a pressure vessel.
参考文献标题:LU-253
文献作者:Blancafort,P.; Neuman,M.; Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1981,6(2),89
合成路线:This compound can be obtained in two different ways:1) By reaction of 4-oxa-5-hydroxytricyclo[5.2.1.0(2,6)]dec-8-en-3-one (I) with methyl isocyanate (II) in refluxing THF.2) By a Diels-Alder reaction of cyclopentadiene (III) with 2-(N-methylcarbamoyloxy)-2,5-dihydrofuran-5 one (IV) in THF at 120 C in a pressure vessel.
参考文献标题:
文献作者:Wiersdorff,W.W.; Wilsmann,K.
参考来源:DE 2510714