项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Sch-32651

Chemical Name: 2-Methyl-8-(phenylmethoxy)imidazo[1,2-a]pyrazin-3-amine monohydrochloride hydrate (3:1); 3-Amino-2-methyl-8-phenylmethoxyimidazo[1,2-a]pyrazine monohydrochloride hydrate (3:1); 3-Amino-...
参考文献标题:Imidazo[1,2-a]pyridines and use
文献作者:Bristol,J.A.; Puchalski,C.(Schering Corp.)
参考来源:EP 0068378; ES 513431; US 4450164

Rotraxate hydrochloride, TEI-5103, Cumelon

Chemical Name: trans-4-[[4-(Aminomethyl)cyclohexyl]carbonyl]benzenepropanoic acid hydrochloride; 3-[p-(trans-4-Aminomethylcyclohexylcarbonyl)phenyl]propionic acid hydrochloride
CAS No. 82085-94-7 参考文献标题:Aminocarboxylic acids,amino alcohols or the derivatives thereof,processes for production thereof and pharmaceutical uses thereof
文献作者:Takeshita,T.; Hoshina,K.; Ohtsu,A.; Naruchi,T.(Teijin Ltd.)
参考来源:CA 1176267; EP 0044541; US 4402975

NCO-700

Chemical Name: Bis[ethyl(2R,3R)-trans-3-[(S)-3-methyl-1-[4-(2,3,4-trimethoxybenzyl)piperazin-1-ylcarbonyl]butylcarbamoyl]oxyran-2-carboxylate]sulfate; [2R-[2alpha,3beta(S*)]]-3-[[[3-Methyl-1-[[4-[(2,3...
参考文献标题:1-Aryloxy-2-hydroxy-3-[(benzimidazolin-one-substituted alkyl)-amino]-propanes and salts thereof
文献作者:Hoefke,W.; et al.(Boehringer Ingelheim GmbH)
参考来源:DE 2644833

GYKI-32887, RGH-7825

Chemical Name: 8-[N-(2-Azidoethyl)-N-(methylsulfonyl)aminomethyl]-6-methylergol-8-ene maleate; N-(2-Azidoethyl)-N-(8,9-didehydro-6-methylergolin-8-ylmethyl)methanesulfonamide maleate
CAS No. 78463-...
参考文献标题:Novel ergol-8-ene and ergolin compounds and process for preparing same
文献作者:Mago,N.K.E.; et al.(Gedeon Richter Ltd.)
参考来源:DE 3026271; HU 180467

D-2343

Chemical Name: 1-(4-Hydroxyphenyl)-2-[1,1-dimethyl-3-(2-methoxyphenyl)propylamino]ethanol hydrochloride; 4-Hydroxy-alpha-[[[3-(2-methoxyphenyl)-1,1-dimethylpropyl]amino]methyl]benzenemethanol hydrochl...
参考文献标题:D-2343
文献作者:Castar,J.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1982,7(1),17

DN-1417

Chemical Name: gamma-Butyrolactone-gamma-carbonylhistidylprolinamide citrate; N-[(Tetrahydro-5-oxo-2-furanyl)carbonyl]-L-histidyl-L-prolinamide citrate
CAS No. 63836-94-2 ((S)-isomer)
项目整合开发状态: ...
参考文献标题:Intermediates and process for preparing olanzapine
文献作者:Larsen,S.D.; Stephenson,G.A.; Bunnell,C.A.; Reutzel,S.M.; Nichols,J.R.(Eli Lilly and Company)
参考来源:US 6020487

ASL-7022

Chemical Name: 6,7-Dihydroxy-2-[[1-(3,4-dihydroxyphenyl)-2-propyl]amino]-1,2,3,4-tetrahydronaphthalene; 6-[[2-(3,4-Dihydroxyphenyl)-1-methylethyl]amino]-5,6,7,8-tetrahydro-2,3-naphthalenediol; 2-[[2-(...
参考文献标题:ASL-7022
文献作者:Castar,J.; Thorpe,P.; Serradell,M.N.
参考来源:Drugs Fut 1984,9(2),94

L-643441

Chemical Name: 3-[3-[3-(1-Piperidinomethyl)phenoxy]propyl]amino-4-amino-1,2,5-thiadiazole 1-oxide; N-[3-[3-(1-Piperidinylmethyl)phenoxy]propyl]-1,2,5-triadiazole-3,4-diamine 1-oxide
CAS No. 78442-3...
参考文献标题:L-643,441
文献作者:Castar,J.; Blancafort,P.; Serradell,M.N.
参考来源:Drugs Fut 1983,8(2),115

TA-077

Chemical Name: 1-(2-Chloroethyl)-3-isobutyl-3-(beta-maltosyl)-1-nitrosourea; 2-[3-(2-Chloroethyl)-1-isobutyl-3-nitrosoureido]-2-deoxy-beta-maltose; 1-(2-Chloroethyl)-3-isobutyl-3-[O-alpha-D-glucopyran...
参考文献标题:TA-077
文献作者:Fujimoto,S.; Ogawa,M.
参考来源:Drugs Fut 1984,9(2),126

ZK-91296

Chemical Name: 5-(Benzyloxy)-4-(methoxymethyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester; 5-(Benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester
CAS No. 83910-34-3<...
参考文献标题:Pharmacologically active 3-substituted beta-carbolines
文献作者:Neef,G.; Eder,U.; Schmiechen,R.; Huth,A.; Rathz,D.; Seidelmonn,D.; Kehr,W.; Palenschat,D.; Braestrup,C.T.; et al.(Schering AG)
参考来源:DD 161210; EP 0054507; ES 8301984; US 4435403; US 4596808