386/1634, FCE-386/1634
Chemical Name: 1,4-Diethyl-5-(N-isopropylthiocarbamoyl)-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine; 1,4-Diethyl-1,4,6,7-tetrahydro-N-(isopropyl)-5H-imidazo[4,5-c]pyridine-5-carbothioamide
CAS No. 70651-76-2
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:The tetahydroimidazopyridine (I) is prepared by condensation of histamine with propionaldehyde in the presence of NaOH.The alkylation in position 1 or 3 is performed with ethyl bromide in a catalytic two-phase system,after protection of the amine group in position 5 as benzyloxycarbonyl derivative,and followed by removal of the protecting group by catalytic hydrogenation.The resulting amines (IVa-b) are then made to react with isopropyl isothiocyanate and the two regioisomers obtained are separated by crystallization.
📌 参考资料/链接：
参考文献标题:4,5,6,7-Tetrahydroimidazo[4,5-c]pyridine derivatives
文献作者:Acari,G.; Bernardi,L.; Falconi,G.; Scarponi,U.(Pharmacia Corp.)
参考来源:BE 0871985; DE 2849572; FR 2433022; GB 2028798; JP 55024158; US 4223146
📄 详细内容
合成路线:The tetahydroimidazopyridine (I) is prepared by condensation of histamine with propionaldehyde in the presence of NaOH.The alkylation in position 1 or 3 is performed with ethyl bromide in a catalytic two-phase system,after protection of the amine group in position 5 as benzyloxycarbonyl derivative,and followed by removal of the protecting group by catalytic hydrogenation.The resulting amines (IVa-b) are then made to react with isopropyl isothiocyanate and the two regioisomers obtained are separated by crystallization.
参考文献标题:386/1634
文献作者:Riva,F.
参考来源:Drugs Fut 1985,10(2),101
产品链接: CAS No. 70651-76-2››