REV-3164, RHC-3164
Chemical Name: 7-Chloro-5-propyl[1,2,4]triazolo[4,3-a]quinoxaline-1,4(2H,5H)-dione
CAS No. 80708-33-4
项目整合开发状态: Biological Testing
项目研究机构: Revlon (Originator)
合成路线:The cyctization of 4-chloro-2-(propylamino)aniline (I) with oxalyl chloride (II) in hot o-dichlorobenzene gives 1-propyl-7-chloroquinoxaline-2,3-dione (III),which by reaction with SOCl2 in DMF is converted to 3,7-dichloro-1-propyl-1H-quinoxalin-2-one (IV).The condensation of (IV) with ethyl carbazate (V) in refluxing acetonitrile affords ethyl 3-(7-chloro-1-propyl-2-oxo-1H-quinoxalin-3-yl)carbazate (VI),which is finally cyclized by heating at 260 C.
📌 参考资料/链接：
参考文献标题:Triazaloquinoxalin-1,4-diones
文献作者:Brown,R.E.; Georgiev,V.; Kropp,P.; Loev,B.(USV Pharmaceutical Corp.)
参考来源:EP 0039920; JP 57004988; US 4400382
📄 详细内容
合成路线:The cyctization of 4-chloro-2-(propylamino)aniline (I) with oxalyl chloride (II) in hot o-dichlorobenzene gives 1-propyl-7-chloroquinoxaline-2,3-dione (III),which by reaction with SOCl2 in DMF is converted to 3,7-dichloro-1-propyl-1H-quinoxalin-2-one (IV).The condensation of (IV) with ethyl carbazate (V) in refluxing acetonitrile affords ethyl 3-(7-chloro-1-propyl-2-oxo-1H-quinoxalin-3-yl)carbazate (VI),which is finally cyclized by heating at 260 C.
参考文献标题:RHC-3164
文献作者:Chu,S.S.; Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1985,10(12),985
产品链接: CAS No. 80708-33-4››