项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

A-317344((R)-isomer), A-317491

Chemical Name: 5-[N-(3-Phenoxybenzyl)-N-[1,2,3,4-tetrahydronaphthalen-1(S)-yl]carbamoyl]benzene-1,2,4-tricarboxylic acid
CAS No. 475205-49-3, 185049-86-9 (undefined isomer)
项目整合开发状态: Preclinical...
参考文献标题:Trisubstd.-N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]benzamides which inhibit P2X3 and P2X2/3 containing receptors
文献作者:Lee,C.-H.; Stewart,A.O.; Perner,R.J.; Zheng,G.Z.; Larson,D.P.; Koenig,J.R.; Gomtsyan,A.R.; Didomenico,S.; Bayburt,E.K.(Abbott Laboratories Inc.)
参考来源:US 2002173665; WO 0294767

新产品编号:619071

Chemical Name: N-[3-[3,5-Difluoro-4-[4-(hydroxyacetyl)piperazin-1-yl]phenyl]-4,5-dihydroisoxazol-5(R)-ylmethyl]acetamide
CAS No. 238743-18-5 ((-)-enantiomer), 194350-87-3 ((S)-isomer)
项目整合开发状态: ...
参考文献标题:Substd.aminophenyl isoxazoline derivs.useful as antimicrobials
文献作者:Thomas,R.C.; Barbachyn,M.R.; Morris,J.; Wishka,D.G.; Cleek,G.J.(Pfizer Inc.)
参考来源:JP 2002503655; US 6069141; WO 9941244

新产品编号:952873

Chemical Name: 1(R)-[4-[3(R),5(S)-Dimethyl-4-(4-methyl-1,3,5-triazin-2-yl)piperazin-1-yl]-1,3,5-triazin-2-yl]ethanol
CAS No. 465530-70-5
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合...
参考文献标题:Triazine cpds.useful as sorbitol dehydrogenase inhibitors
文献作者:Mylari,B.L.(Pfizer Products Inc.)
参考来源:EP 1247809

新产品编号:812075

Chemical Name: 4(R)-Hydroxy-1-(3,3,3-triphenylpropionyl)-L-prolyl-N-[1-propylpiperidin-3(R)-ylmethyl]-D-prolinamide
CAS No. 323182-47-4, 323182-76-9 (diastereomer)
项目整合开发状态: Biological Testing 参考文献标题:Novel amide derivs.
文献作者:Kimura,T.; Noguchi,K.; Otake,N.; Uchiyama,M.; Naya,A.; Sagara,Y.; Numazawa,T.; Fujikawa,T.(Banyu Pharmaceutical Co.,Ltd.)
参考来源:EP 1213281; WO 0107406

RO-09-8325

Chemical Name: 1-(1-Allyl-1H-benzimidazol-2-yl)-1-[3-methyl-4-[3-(pyridin-3-ylmethylamino)propoxy]-1-benzofuran-2-yl]methanone
CAS No. 445510-12-3
项目整合开发状态: Preclinical
项目研究机构: Chugai (Origin...
参考文献标题:Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase.Part 3
文献作者:Kawasaki,K.; Masubuchi,M.; Morikami,K.; Sogabe,S.; Aoyama,T.; Ebiike,H.; Niizuma,S.; Hayase,M.; Fujii,T.; Sakata,K.; Shindoh,H.; Shiratori,Y.; Aoki,Y.; Ohtsuka,T.; Shimma,N.
参考来源:Bioorg Med Chem Lett 2003,13(1),87

新产品编号:864281

Chemical Name: 7-[2-Chloro-4-(difluoromethoxy)phenyl]-3-(1-cyclobutylethyl)-2-ethyl-3H-imidazo[4,5-b]pyridine
CAS No. 345226-13-3
项目整合开发状态: Preclinical
项目研究机构: Bristol-Myers Squibb (Originato...
参考文献标题:Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands
文献作者:Arvanitis,A.G.; Rescinito,J.T.; Arnold,C.R.; Wilde,R.G.; Cain,G.A.; Sun,J.H.; Yan,J.-S.; Teleha,C.A.; Fitzgerald,L.W.; McElroy,J.; Zaczek,R.; Hartig,P.R.; Grossman,S.; Arneric,S.P.; Gilligan,P.J.; Olson,R.E.; Robertson,D.W.
参考来源:Bioorg Med Chem Lett 2003,13(1),125

新产品编号:865863

Chemical Name: 4-[2-Chloro-4-(trifluoromethoxy)phenyl]-2-ethyl-1-[1(S)-methylbutyl]-1H-imidazo[4,5-c]pyridine
CAS No. 345226-18-8 (undefined stereoch.)
项目整合开发状态: Preclinical
项目研究机构: Bristol-M...
参考文献标题:Imidazopyrimidinyl and imidazopyridinyl derivs.
文献作者:Wilde,R.G.; Bakthavatchalam,R.; Beck,J.P.; Arvanitis,A.(Bristol-Myers Squibb Co.)
参考来源:EP 1244666; JP 2003516992; WO 0144248

新产品编号:783599

Chemical Name: 3-Cyclopropyl-2(R)-[3(S)-[4-[3,3-difluoro-3-(4-fluorophenyl)propyl]piperidin-1-ylmethyl]-4(S)-(3-fluorophenyl)pyrrolidin-1-yl]propionic acid
CAS No. 301183-74-4
项目整合开发状态: Preclini...
参考文献标题:Pyrrolidine modulators of chemokine receptor activity
文献作者:Mills,S.G.; Kim,D.; Hale,J.; MacCoss,M.; Berk,S.; Chapman,K.; Lynch,C.; Caldwell,C.; Willoughby,C.; Rosauer,K.(Merck & Co.,Inc.)
参考来源:US 6265434; WO 0059503

新产品编号:400755

Chemical Name: 3-[4-[2-[4-[3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl]piperidin-1-yl]-2-oxoethyl]-1-piperidinyl]-3-oxopropionamide
CAS No. 210646-43-8
项目整合...
参考文献标题:Cpds.useful for inhibition of farnesyl protein transferase
文献作者:Doll,R.J.; Njoroge,F.G.; Remiszewski,S.W.; Taveras,A.G.; Lalwani,T.; Alvarez,C.(Schering Corp.)
参考来源:US 6030982

MRK-A, CMPD-167, MRK-1

Chemical Name: N-[(1R,3S,4S)-3-[4-(3-Benzyl-1-ethyl-1H-pyrazol-5-yl)piperidin-1-ylmethyl]-4-(3-fluorophenyl)cyclopentyl]-N-methyl-D-valine
CAS No. 313994-79-5, 313991-37-6 (triHCl)
项目整合开发状态: Pre...
参考文献标题:N-Cyclopentyl modulators of chemokine receptor activity
文献作者:Finke,P.E.; Shah,S.K.; Guthikonda,R.N.; Mills,S.G.; Kim,D.; Chapman,K.T.; MacCoss,M.; Oates,B.; Shen,D.-M.; Loebach,J.L.; Hilfiker,K.A.(Merck & Co.,Inc.)
参考来源:EP 1192133; JP 2003502315; WO 0076972