A-317344((R)-isomer), A-317491
Chemical Name: 5-[N-(3-Phenoxybenzyl)-N-[1,2,3,4-tetrahydronaphthalen-1(S)-yl]carbamoyl]benzene-1,2,4-tricarboxylic acid
CAS No. 475205-49-3, 185049-86-9 (undefined isomer)
项目整合开发状态: Preclinical
项目研究机构: Abbott (Originator)
合成路线:The reductive alkylation of (S)-1,2,3,4-tetrahydro-1-naphthalenylamine (I) with 3-phenoxybenzaldehyde (II) in the presence of NaBH4 affords the secondary amine (III),which is then acylated with 1,2,4,5-benzenetetracarboxylic dianhydride (IV),followed by aqueous hydrolysis to furnish the title compound.
📌 参考资料/链接：
参考文献标题:Trisubstd.-N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]benzamides which inhibit P2X3 and P2X2/3 containing receptors
文献作者:Lee,C.-H.; Stewart,A.O.; Perner,R.J.; Zheng,G.Z.; Larson,D.P.; Koenig,J.R.; Gomtsyan,A.R.; Didomenico,S.; Bayburt,E.K.(Abbott Laboratories Inc.)
参考来源:US 2002173665; WO 0294767