项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

SIM-01

Chemical Name: 5,15-Bis(3,5-dihydroxyphenyl)-7,8,21,23-tetrahydroporphine; 5,5'-(7,8,21,23-Tetrahydroporphine-5,15-diyl)bis(benzene-1,3-diol)
CAS No. 394661-77-9
项目整合开发状态: Preclinical
项目研究机构:...
参考文献标题:Dihydroporphyrin derivs.and their uses
文献作者:Bourre,L.; Patrice,T.
参考来源:EP 1305317; FR 2812637; US 2004022734; WO 0210173

ANTI

Chemical Name: N-[2-[(4bS,8R,8aS,14bR)-7-(Cyclopropylmethyl)-1,8a-dihydroxy-5,6,7,8,8a,9,14,14b-octahydro-4,8-methano[1]benzofuro[2,3-a]pyrido[4,3-b]carbazol-11-yl]ethyl]acetamidine; N-[2-[17-(Cyclopr...
参考文献标题:Potent and selective indolomorphinan antagonists of the kappa-opioid receptor
文献作者:Stevens,W.C.; Jones,R.M.; Subramanian,G.; Metzger,T.G.; Ferguson,D.M.; Portoghese,P.S.
参考来源:J Med Chem 2000,43(14),2759

新产品编号:676023

Chemical Name: 1-[2'-[N-(3,4-Dimethylisoxazol-5-yl)sulfamoyl]-2-methylbiphenyl-4-ylmethyl]-4-ethyl-N-methyl-2-propyl-1H-imidazole-5-carboxamide
CAS No. 254740-41-5
项目整合开发状态: Preclinical
项目研究机...
参考文献标题:Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
文献作者:Macor,J.E.; Murugesan,N.; Gu,Z.; Tellew,J.E.(Bristol-Myers Squibb Co.)
参考来源:EP 1094816; JP 2002519380; US 2002143024; WO 0001389

新产品编号:956037

Chemical Name: (3S,6R,9S,12R,15S)-9-[1(S)-Hydroxy-1-[2-iminoimidazolidin-4(S)-yl]methyl]-6-[1(S)-hydroxy-1-[2-imino-3-(alpha-D-mannopyranosyl)imidazolidin-4(S)-yl]methyl]-3-(hydroxymethyl)-12-[4-[4-O-...
参考文献标题:Glycopeptide antibiotics
文献作者:Sum,P.-E.; Newman,H.; Greenstein,M.; Sakya,S.; He,H.; Dushin,R.G.; Lang,S.A.; Abbanat,D.R.; Bernan,V.S.; Sutherland,A.G.; Wang,T.-Z.; Ruppen,M.E.; Bailey,A.E.; Chi,P.; Shen,B.; Kong,F.; Lotvin,J.A.(Wyeth)
参考来源:WO 0285307

新产品编号:217243

Chemical Name: N-Ethyl-4-[6-methoxy-2,3-dihydro-1H-inden-1(R)-yl]piperazine-1-carboxamide
CAS No. 189254-14-6
项目整合开发状态: Preclinical
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:Reductive...
参考文献标题:Novel melatonergic indanyl piperazines or homopiperazines
文献作者:Mattson,R.J.; Sloan,C.P.; Catt,J.D.(Bristol-Myers Squibb Co.)
参考来源:CA 2175395; EP 0745597

新产品编号:652293

Chemical Name: 2-[(1R,2S)-2-(3,5-Dibromo-2-ethoxybenzylamino)cyclopentylmethylamino]quinolin-4(1H)-one
CAS No. 248607-39-8
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmithKline (Originator) 参考文献标题:Quinolones used as MRS inhibitors and bactericides
文献作者:Berge,J.M.; Forrest,A.K.; Elder,J.S.; Jarvest,R.L.; Brown,P.; McNair,D.J.; Hamprecht,D.W.; Sheppard,R.J.(GlaxoSmithKline plc)
参考来源:EP 1084110; JP 2002513005; US 6320051; WO 9955677

新产品编号:924397

Chemical Name: (?-2-[N-[4-[2-Acetamido-2-(N-pentylcarbamoyl)ethyl]-2-(2-hydroxyethyl)phenyl]-N-(2-hydroxyoxalyl)amino]benzoic acid; N-[4-[2-Acetamido-2-(N-pentylcarbamoyl)ethyl]-2-(2-hydroxyethyl)phen...
参考文献标题:Amino(oxo)acetic acid protein tyrosine phosphatase inhibitors
文献作者:Liu,G.; Janowick,D.A.; Szczepankiewicz,B.G.; Xin,Z.; Pei,Z.; Oost,T.K.(Abbott Laboratories Inc.)
参考来源:WO 0218323

新产品编号:968693

Chemical Name: (15alpha,17beta)-3,17-Dihydroxyestra-1,3,5(10)-triene-15-carboxylic acid ethyl ester
CAS No. 534572-73-1
项目整合开发状态: Preclinical
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路...
参考文献标题:Synthesis and evaluation of B-,C-,and d-ring-substituted estradiol carboxylic acid esters as locally active estrogens
文献作者:Labaree,D.C.; Zhang,J.; Harris,H.A.; O'Connor,C.; Reynolds,T.Y.; Hochberg,R.B.
参考来源:J Med Chem 2003,46(10),1886

新产品编号:706081

Chemical Name: N-(6-Amino-2-methylpyridin-3-ylmethyl)-2-[2-(cyclopropylmethyl)-7-methyl-1,1,5-trioxo-3,4,5,6-tetrahydro-2H-pyrido[3,4-e][1,2,4]thiadiazin-6-yl]acetamide
CAS No. 262616-78-4, 262616-...
参考文献标题:Thrombin inhibitors
文献作者:Sanderson,P.E.; Cutrona,K.(Merck & Co.,Inc.)
参考来源:EP 1117660; JP 2002525370; US 6117888; WO 0018762

新产品编号:411829

Chemical Name: 2-(4-Methoxyphenylsulfonyl)-2-methyl-3-[4-[2-(1-piperidinyl)ethoxy]phenyl]propionohydroxamic acid
CAS No. 212766-10-4
项目整合开发状态: Preclinical
项目研究机构: Wyeth Pharmaceuticals (Origi...
参考文献标题:N-Hydroxy-2-(alkyl,aryl or heteroaryl sulfanyl,sulfinyl or sulfonyl)-3-substd.alkyl,aryl or heteroarylamides as matrix metalloproteinase inhibitors
文献作者:Venkatesan,A.M.; Grosu,G.T.; Davis,J.M.; Baker,J.L.(Wyeth)
参考来源:EP 0970046; EP 0973512; JP 2001513771; JP 2001519777; WO 9837877; WO 9838163