项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

新产品编号:271031

Chemical Name: 2-[3-[4-(3-Phenyl-7-propyl-1,2-benzisoxazol-6-yloxy)butoxy]phenyl]acetic acid sodium salt
CAS No. 194980-75-1 (free acid), 477936-07-5 (labeled)
项目整合开发状态: Preclinical
项目研究机构: M...
参考文献标题:Heterocyclic derivs.as antidiabetic and antiobesity agents
文献作者:Adams,A.D.; Berger,J.P.; Berger,G.D.; Fitch,K.J.; Graham,D.W.; Jones,A.B.; Von Langen,D.; Leibowitz,M.D.; Moller,D.E.; Patchett,A.A.; Santini,C.; Sahoo,S.P.; Tolman,R.L.; Toupence,R.B.; Walsh,T.F.(Merck & Co.,Inc.)
参考来源:EP 0882029; JP 2002503203; US 6090836; WO 9728137

14-Pivaloylandrographolide

Chemical Name: 2,2-Dimethylpropionic acid (3S,4E)-4-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methyleneperhydronaphthalen-1-yl]ethylidene]-5-oxotetrahydrofuran-3-yl ester
C...
参考文献标题:Novel anticancer cpds.: Process for their preparation and pharmaceutical compsns.containing them
文献作者:Chakrabarti,R.; Akella,V.; Nanduri,S.; Rajagopal,S.; Pothukuchi,S.; Pillai,S.B.K.(Dr.Reddy's Research Foundation)
参考来源:US 2002016363; US 6486196; WO 0185710

新产品编号:900667

Chemical Name: Acetic acid (1R,2R,4aS,5R,8aS)-2-acetoxy-5-[2-[N-benzyl-N-(2-chloroacetyl)amino]-2-(2-oxo-2,5-dihydrofuran-3-yl)ethyl]-1,4a-dimethyl-6-methyleneperhydronaphthalen-1-ylmethyl ester
CA...
参考文献标题:New cpds.having anticancer activity: Process for their preparation and pharmaceutical compsns.containing them
文献作者:Akella,V.; Nanduri,S.; Rajagopal,S.(Dr.Reddy's Research Foundation)
参考来源:US 6576662; WO 0185709

新产品编号:940217

Chemical Name: N-[2-(Aminomethyl)-5-chlorobenzyl]-2-[6-chloro-3-[2,2-difluoro-2-(1-oxidopyridin-2-yl)ethylamino]-2-oxo-1,2-dihydropyrazin-1-yl]acetamide
CAS No. 443900-48-9
项目整合开发状态: Biological ...
参考文献标题:Thrombin inhibitors
文献作者:Selnick,H.G.; Rittle,K.E.; Barrow,J.C.; Morrissette,M.M.; Nantermet,P.G.; Staas,D.(Merck & Co.,Inc.)
参考来源:WO 0257225

新产品编号:829477

Chemical Name: 5-(3',5'-Di-tert-butyl-2'-propoxybiphenyl-2-yl)-3-methyl-2,4-pentadienoic acid sodium salt
CAS No. 331248-51-2 (free acid)
项目整合开发状态: Preclinical
项目研究机构: Ligand (Originator), Li...
参考文献标题:RXR modulators with improved pharmacologic profile
文献作者:Jones,T.K.; Ardecky,R.J.; Boehm,M.F.; Hamann,L.G.; Thompson,A.J.; Michellys,P.-Y.; Tyhonas,J.S.; Faulkner,A.L.; Mapes,C.M.; Chen,J.-H.(Ligand Pharmaceuticals,Inc.)
参考来源:EP 1216221; WO 0119770

PG-766969

Chemical Name: N-[3-[4-[1-(Ethoxymethyl)-4-(4-fluorophenyl)-1H-1,2,3-triazol-5-yl]pyrimidin-2-yloxy]phenyl]acetamide
CAS No. 474513-10-5
项目整合开发状态: Preclinical
项目研究机构: Procter & Gamble (Origin...
参考文献标题:Triazole cpds.useful in treating diseases associated with unwanted cytokine activity
文献作者:De,B.; Natchus,M.G.; Blass,B.E.; Tullis,J.S.; Van Rens,J.C.; Clark,M.P.(The Procter & Gamble Co.)
参考来源:EP 1383759; WO 0288108

新产品编号:566865

Chemical Name: 2-(1-Methyl-1H-imidazol-2-yl)-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine
CAS No. 225382-65-0
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:Decarb...
参考文献标题:Thienopyrimidine and thienopyridine derivs.useful as anticancer agents
文献作者:Sobolov-Jaynes,S.B.; Munchhof,M.J.(Pfizer Products Inc.)
参考来源:EP 1028964; JP 2001522853; WO 9924440

ttCH

Chemical Name: 1-[2-(Trifluoromethyl)phenyl]-3-(2,4,6-trimethoxyphenyl)-2-propen-1-one
CAS No. 478688-41-4
项目整合开发状态: Preclinical
项目研究机构: Universidad Central de Venezuela (Originator), Univers...
参考文献标题:The synthesis and effect of fluorinated chalcone derivatives on nitric oxide production
文献作者:Rojas,J.; Pay? M.; Dominguez,J.N.; Ferr醤diz,M.L.
参考来源:Bioorg Med Chem Lett 2002,12(15),1951

新产品编号:467199

Chemical Name: 4-(3-Bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-[3-(1H-imidazol-1-yl)propyl]piperazine-1,2(R)-dicarboxamide isomer B
CAS No. 218792-48-...
参考文献标题:Benzpyrido cycloheptane cpds.useful for inhibition of farnesyl protein transferase
文献作者:Baldwin,J.J.; Cooper,A.B.; Girijavallabhan,V.M.; Ganguly,A.; Reader,J.C.; Huang,C.(Pharmacopeia,Inc.; Schering Corp.)
参考来源:EP 0989983; JP 2002504144; WO 9857960

新产品编号:960783

Chemical Name: 11(S)-Benzyl-6-chloro-1,2,10,11,12,13,14,15,16,17,18,19-dodecahydro-5,9-methano-2,5,8,10,13,17-benzohexaazacyclohenicosine-3,24-dione
CAS No. 496917-61-4, 496917-60-3 (triHCl)
项目整...
参考文献标题:Thrombin inhibitors
文献作者:Selnick,H.G.; Newton,R.C.; Newton,C.L.; Barrow,J.C.; Nantermet,P.G.(Merck & Co.,Inc.)
参考来源:WO 0311222