新产品编号:900667
Chemical Name: Acetic acid (1R,2R,4aS,5R,8aS)-2-acetoxy-5-[2-[N-benzyl-N-(2-chloroacetyl)amino]-2-(2-oxo-2,5-dihydrofuran-3-yl)ethyl]-1,4a-dimethyl-6-methyleneperhydronaphthalen-1-ylmethyl ester
CAS No. 372939-34-9
项目整合开发状态: Preclinical
项目研究机构: Dr. Reddy's Research Foundation (Originator)
合成路线:Conjugate addition of benzylamine to 3,14,19-triacetyl andrographolide (I) with concomitant elimination of the 14-acetoxy group leads to the butenolide derivative (II).The amino group of (II) is then acylated by chloroacetyl chloride in the presence of Et3N to produce the title chloroacetamide (1,2)
📌 参考资料/链接：
参考文献标题:New cpds.having anticancer activity: Process for their preparation and pharmaceutical compsns.containing them
文献作者:Akella,V.; Nanduri,S.; Rajagopal,S.(Dr.Reddy's Research Foundation)
参考来源:US 6576662; WO 0185709
📄 详细内容
合成路线:Conjugate addition of benzylamine to 3,14,19-triacetyl andrographolide (I) with concomitant elimination of the 14-acetoxy group leads to the butenolide derivative (II).The amino group of (II) is then acylated by chloroacetyl chloride in the presence of Et3N to produce the title chloroacetamide (1,2)
参考文献标题:Synthesis and SAR studies of C-12 substituted andrographolide analogs as novel anticancer agents
文献作者:Nanduri,S.; Thunuguntla,S.S.R.; Nyavanandi,V.K.; Akella,V.; Deevi,D.S.; Kasu,S.; Pallerla,M.K.; Rajagopal,S.; Ramanujam,R.; Reka,A.K.; et al.
参考来源:225th ACS Natl Meet (March 23 2003,New Orleans) 2003,Abst MEDI 94