CP-8668

Chemical Name: N-Propylcarbamic acid (4aR,5R,6R,7R)-7-methoxy-1,3,4a,5-tetramethyl-2-oxo-2,4,4a,5,6,7-hexahydro-1H-benzo[f]indol-6-yl ester
CAS No. 209331-43-1
项目整合开发状态: Preclinical
项目研究机构: Meiji Seika (Originator)
合成路线:Treatment of lactone (I) with methanesulfonyl chloride,followed by reaction with methylamine furnishes amide (II).This is subsequently cyclized to the benzoindolone derivative (III) in the presence of AcOH in acetonitrile.The acetate group of (III) is then displaced by a methoxy group to give (IV) upon heating in MeOH.Finally,condensation of (IV) with propyl isocyanate (V) provides the title N-propyl carbamate.