新产品编号:949709
Chemical Name: 1-[4-[4-(Pyrrolidin-1-ylmethyl)benzyloxy]phenyl]ethanone oxalate
CAS No. 462115-49-7, 462115-48-6 (free base)
项目整合开发状态: Preclinical
项目研究机构: Bioprojet (Originator)
合成路线:Condensation of alpha,alpha'-dibromo-p-xylene (I) with 4-hydroxyacetophenone (II) in the presence of K2CO3 affords 4-[(4-bromomethyl)benzyloxy]acetophenone (III).Subsequent condensation of bromide (III) with pyrrolidine,followed by conversion to the corresponding oxalate salt furnishes the title compound.
📌 参考资料/链接：
参考文献标题:Non-imidazole alkylamines as histamine H3-receptor ligands and their therapeutic applications
文献作者:Schwartz,J.-C.; Lecomte,J.-M.; Arrang,J.-M.; Garbarg,M.; Ganellin,C.R.; Stark,H.; Ligneau,X.; Schunack,W.G.; Leurquin,F.; Sigurd,E.(Societe Civile Bioprojet)
参考来源:EP 1100503; EP 1428820; WO 0006254
📄 详细内容
合成路线:Condensation of alpha,alpha'-dibromo-p-xylene (I) with 4-hydroxyacetophenone (II) in the presence of K2CO3 affords 4-[(4-bromomethyl)benzyloxy]acetophenone (III).Subsequent condensation of bromide (III) with pyrrolidine,followed by conversion to the corresponding oxalate salt furnishes the title compound.
参考文献标题:Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(Phenoxymethyl)benzyl)piperidines and related compounds
文献作者:Mik? T.; Ligneau,X.; Pertz,H.H.; Ganellin,C.R.; Arrang,J.-M.; Schwartz,J.-C.; Schunack,W.; Stark,H.
参考来源:J Med Chem 2003,46(8),1523