新产品编号:805747
Chemical Name: (T-4)-Tetrakis[(phosphinidyne-kappaP)tris(methanol)]gold(+1) chloride; Tetrakis[tris(hydroxymethyl)phosphine]gold(I) chloride
CAS No. 313695-66-8, 193076-00-5 (sodium salt)
项目整合开发状态: Preclinical
项目研究机构: University of Missouri (Originator)
合成路线:Treatment of an aqueous solution of sodium tetrachloroaurate (I) with an excess of tris(hydroxymethyl)phosphine (II) causes the reduction from gold(III) to gold(I) oxidation state,with concomitant complexation with the phosphine to produce the target tetrakis(phosphine) gold complex.(1,2)
📌 参考资料/链接：
参考文献标题:Gold-containing chemotherapeutic agents
文献作者:Kamei,H.; Katti,K.V.; Volkert,W.A.; Hoffman,T.J.(University of Missouri)
参考来源:WO 0078306
📄 详细内容
合成路线:In an alternative method,triphenylphosphinegold(I) chloride (I) is complexed to tris(hydroxymethyl)phosphine (II) to furnish the title compound.
参考文献标题:In vitro and in vivo antitumor properties of tetrakis((trishydroxy-methyl)phosphine)gold(I) chloride
文献作者:Pillarsetty,N.; Katti,K.K.; Hoffman,T.J.; Volkert,W.A.; Katti,K.V.; Kamei,H.; Koide,T.
参考来源:J Med Chem 2003,46(7),1130
合成路线:Treatment of an aqueous solution of sodium tetrachloroaurate (I) with an excess of tris(hydroxymethyl)phosphine (II) causes the reduction from gold(III) to gold(I) oxidation state,with concomitant complexation with the phosphine to produce the target tetrakis(phosphine) gold complex.(1,2)
参考文献标题:Hydroxymethyl functionalized phosphanes as building blocks to new water-soluble gold(I) complexes - Synthesis,characterization,and X-ray crystal structures of novel tetrahedral [Au{P(CH2OH)3}4]+ and trigonal planar Au(Ph2PCH2OH)3]+ gold(I) complexes
文献作者:Berning,D.E.; Katti,K.V.; Barnes,C.L.; Volkert,W.A.
参考来源:Chem Ber 1997,130(7),907