新产品编号:769361
Chemical Name: N,N'-(1,3-Propylene)bis(oxy)bis(naphthalen-7,1-diyl)bis(1,2-ethylene)bis(acetamide)
CAS No. 296280-56-3
项目整合开发状态: Biological Testing
项目研究机构: Servier (Originator)
合成路线:Demethylation of N-[2-(7-methoxynaphth-1-yl)ethyl]acetamide (I) with boron tribromide-dimethyl sulfide complex affords phenol (II).This is then alkylated with 3-bromopropanol (III) in the presence of K2CO3 to provide the hydroxypropyl derivative (IV).After conversion of alcohol (IV) into the corresponding mesylate (V),condensation with a further equivalent of phenol (II) in hot DMF furnishes the target dimeric compound
📌 参考资料/链接：
参考文献标题:Substd.dimeric cpds.,process for their preparation and pharmaceutical compsns.thereof
文献作者:Guillaumet,G.; Renard,P.; Lesieur,D.; Yous,S.; Descamps-Francois,C.; Lefoulon,F.; Viaud,M.-C.; Delagrange,P.; Bennejean,C.(ADIR et Cie.)
参考来源:EP 1038863; FR 2791344; JP 2000319242; US 2002035114; US 6319930; US 6635650
📄 详细内容
合成路线:In an alternative method,the title dimer compound is obtained by condensation of two equivalents of N-[2-(7-hydroxynaphth-1-yl)ethyl]acetamide (I) with 1,3-dibromopropane (II) in the presence of K2CO3 in acetonitrile
参考文献标题:Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands
文献作者:Descamps-Fran鏾is,C.; Yous,S.; Chavatte,P.; Audinot,V.; Bonnaud,A.; Boutin,J.A.; Delagrange,P.; Bennejean,C.; Renard,P.; Lesieur,D.
参考来源:J Med Chem 2003,46(7),1127
产品链接: CAS No. 296280-56-3››