项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Trombodipine, PCA-4230

Chemical Name: 2,4,6-Trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 2-(1,1-dioxido-3-oxo-2,3-dihydro-1,2-benzisothiazol-2-yl)ethyl ethyl diester
CAS No. 113658-85-8
项目整合开发状态: Phase II
项目...
参考文献标题:1,4-Dihydropyridines,processes for their preparation and their use as antithrombotic drugs
文献作者:Sunkel,C.; Fau de Casa-Juana,M.; Dorrego,F.; Priego,J.; Ortega,P.; Cillero,J.(Alter SA)
参考来源:DE 3617976; EP 0253092; US 4782069

Cerebrocrast, IOS-1.1212

Chemical Name: 4-[2-(Difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid di(2-propoxyethyl) diester
CAS No. 108863-62-3
项目整合开发状态: Phase I
项目研究机构: Latvian Institute ...
参考文献标题:Alkoxy- and phenoxy-alkyl esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid
文献作者:Makarova,N.V.; Biseniex,E.A.; Uldrikis,Y.R.; Dubur,G.Y.; Veveris,M.M.; Kimenis,A.A.(Latvian Institute of Organic Synthesis)
参考来源:FR 2587701

Elliprabin, Ellipravin, SUN-4599

Chemical Name: 9-Hydroxy-5,11-dimethyl-2-(3alpha,4beta,5beta-trihydroxytetrahydropyran-2beta-yl)-6H-pyrido[4,3-b]-carbazolium bromide; 9-Hydroxy-5,11-dimethyl-2-(alpha-L-arabinopyranosyl)-6H-pyrido[4,...
参考文献标题:Ellipticine derivs.
文献作者:Honda,T.; Nakanishi,T.(Suntory Ltd.)
参考来源:AU 8545252; EP 0173462; JP 1986037799; JP 1987022794; JP 1987022795; JP 1987030795; US 4698423

Wy-47288

Chemical Name: 2-(1-Naphthyloxymethyl)quinoline
CAS No. 110033-17-5
项目整合开发状态: Preclinical
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:By condensation of 1-naphthol (I) with 2-(chlorome...
参考文献标题:Conversion of a cyclooxygenase (CO) inhibitor into a 5-lipoxygenase (LO) inhibitor - A general route to novel antiinflammatory and antiallergy drugs
文献作者:Kreft,A.F.; Failli,A.; Musser,J.H.; et al.
参考来源:Drugs Exp Clin Res 1991,17381-387

NDDP

Chemical Name: cis-Bis(neodecanoato)(trans-R,R-1,2-diaminocyclohexane)platinum II; cis-Bis(2,2-dimethyloctanoato)[trans-1(R),2(R)-diaminocyclohexane]platinum (II)
CAS No. 114488-24-3
项目整合开发状态: P...
参考文献标题:Chemical and biological studies on a series of lipid-soluble (trans-(R,R)- and -(S,S)-1,2-diaminocyclohexane)platinum(II) complexes incorporated in liposomes
文献作者:Perez-Soler,R.; Brown,T.; Khokhar,A.R.; Al-Baker,S.
参考来源:J Med Chem 1991,34(1),325-9

Cericlamine hydrochloride, JO-1017

Chemical Name: (?-3-(3,4-Dichlorophenyl)-2-(dimethylamino)-2-methylpropanol hydrochloride; (?-3,4-Dichloro-beta-(dimethylamino)-beta-methylbenzenepropanol hydrochloride
CAS No. 112922-72-2, 112922-...
参考文献标题:Aminoalcohols,process for their preparation and their applications,notable in therapy
文献作者:Aubard,G.; Bure,J.; Calvet,A.P.; Gouret,C.; Grouhel,A.G.; Junien,J.-L.(Institut de Recherche Jouveinal)
参考来源:EP 0237366; FR 2593499; JP 1987190150

CGP-29861

Chemical Name: 3-Formylrifamycin SV hydrazone with 2-amino-7-ethylperhydro-1H-pyrido[1,2-a]pyrazine; 21-Acetoxy-8-(7-ethyloctahydropyrido[1,2-a]pyrazin-2-yliminomethyl)-5,6,9,17,19-pentahydroxy-23-met...
参考文献标题:Novel polycyclic hydrazones of rifamycins,their manufacture,and their pharmaceutical compsns.for treating tuberculosis
文献作者:Traxler,P.(Novartis Corp.)
参考来源:US 4681938

CGP-7040

Chemical Name: 3-[4-(2,4,6-Trimethylbenzyl)piperazin-1-yl]rifamycin SV
CAS No. 109006-01-1
项目整合开发状态: Preclinical
项目研究机构: Novartis (Originator)
合成路线:This compound has been obtained by two r...
参考文献标题:Process for the preparation of a peptide derivative of the lysergic acid
文献作者:(Novartis AG)
参考来源:CH 282603

Technetium (99mTc) sestamibi, MIBI-[99mTc], [99mTc]-MIBI, Tc-MIBI, RP-30, Miraluma, Cardiolite

Chemical Name: Hexakis(2-methoxy-2-methylpropylisocyanide)[99mTc]technetium(1+); Hexakis(2-methoxyisobutylisonitrile)[99mTc]technetium
CAS No. 109581-73-9
项目整合开发状态: Launched
项目研究机构: Bristol-M...
参考文献标题:Ether isonitriles and radilabeled complexes thereof
文献作者:Bergstein,P.L.; Subramanyam,V.(E.I.Du Pont de Nemours & Co.)
参考来源:AU 8666842; EP 0233368; JP 87201363

KRI-1314

Chemical Name: 4-Cyclohexyl-2(R)-hydroxy-3(S)-[N-[3-(morpholinocarbonyl)-2(R)-(1-naphthylmethyl)propionyl]-L-histidylamino]butyric acid isopropyl ester; (2R,3S)-4-Cyclohexyl-2-hydroxy-3-[N-[(2R)-2-mor...
参考文献标题:7-Acyloxy-6-aminoacyloxypolyoxylabdanes,process for their preparation and their use
文献作者:Khandewal,Y.; Rajgopalan,R.; Dohadwalla,A.N.; Rupp,R.H.; De Souza,N.J.(Aventis SA)
参考来源:DE 3623300; EP 0252482; JP 1988023878