项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

BMY-25174

Chemical Name: [5R-[5alpha,6alpha(R*)]]-2-[2-Carboxy-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-ylsulfanylmethyl]-1-methylpyridinium hydroxide,inner salt; (5R,6S)-6-[1(R)-Hydroxyethyl]-3-...
参考文献标题:Carbapenem antibiotics
文献作者:Kim,C.U.(Bristol-Myers Squibb Co.)
参考来源:DE 3334937; GB 2128187; US 4644061

LY-195448

Chemical Name: (R)-4-[3-[(2-Hydroxy-2-phenylethyl)amino]-3-methylbutyl]benzamide
CAS No. 74249-21-1 (monoHCl, no stereoch.), 74249-20-0 (undefined stereoch.)
项目整合开发状态: Phase I
项目研究机构: Lilly (...
参考文献标题:Phenethanolamines,their formulations,preparation
文献作者:Mills,J.; Schmiegel,K.K.; Toomey,R.E.(Eli Lilly and Company)
参考来源:EP 0007206

CGP-31608

Chemical Name: (5R,6S,1'R)-2-(Aminomethyl)-6-(1'-hydroxyethyl)-penem-3-carboxylic acid
CAS No. 107740-67-0
项目整合开发状态: Phase I
项目研究机构: Novartis (Originator)
合成路线:Substitution with sodium [N-...
参考文献标题:CGP-31608
文献作者:Cozens,R.M.; Lang,M.
参考来源:Drugs Fut 1988,13(1),19

新产品编号:11583

Chemical Name: 1-beta-D-Arabinofuranosylcytosine 5'-diphosphate-rac-1-O-hexadecyl-2-O-palmitoylglycerol disodium salt
CAS No. 103383-66-0
项目整合开发状态: Biological Testing
项目研究机构: Roswell Park Mem...
参考文献标题:Thiophospholipid conjugates of antitumor agents
文献作者:(Health Research,Inc.)
参考来源:EP 0183843; US 4622392; WO 8600309

IVX-Q-101, WAX-120337, AS-101, Ossirene

Chemical Name: Ammonium trichloro(dioxyethylene-O,O')tellurate
CAS No. 106566-58-9
项目整合开发状态: Phase III
项目研究机构: Bar-Ilan University (Originator), Baker Norton (Licensee)
合成路线:A new synthesi...
参考文献标题:Synthesis and properties of ammonium trichloro(dioxyethylene-O,O')tellurate (AS-101).A new immunomodulating compound
文献作者:Tamari,T.; Sredni,B.; Albeck,M.
参考来源:Synthesis 1989,8(8),635

SS-555

Chemical Name: 6,6'-Di-O-octanoyl-alpha,alpha-trehalose; 6-O-Octanoyl-alpha-D-glucopyranosyl alpha-D-glucopyranoside 6-octanoate
CAS No. 84396-33-8
项目整合开发状态: Preclinical
项目研究机构: Japan Tobacco...
参考文献标题:Antitumor formulation containing lipopolysaccharide with trehalose derivs.
文献作者:Fukushi,K.(SSP Co.,Ltd.)
参考来源:US 4612304

Technetium (99mTc) Teboroxime, CDO-MeB, TEBO, TcCl(CDO)3BMe, SQ-30217, CardioTec

Chemical Name: [Bis[(1,2-cyclohexanedione dioximato)(1-)-O][(1,2-cyclohexanedione dioximato)(2-)-O]methylborato(2-)-N,N',N'',N''',N'''',N''''']chloro[99mTc]technetium(III); Chloro[methylboron(1-)tris[...
参考文献标题:Monocapped tris(dioxime) complexes of technetium(III): Synthesis and structural characterization of TcX(dioxime)3B-R (X = Cl,Br; dioxime = dimethylglyoxime,cyclohexanedione dioxime; R = CH3,C4H9)
文献作者:Treher,E.N.; Francesconi,L.C.; Gougoutas,J.Z.; Malley,M.F.; Nunn,A.D.
参考来源:Inorg Chem 1989,283411-6

(-)-(S)-Bromofosfamide, CBM-11

Chemical Name: 3-(2-Bromoethyl)-N-(2-chloroethyl)-2H-tetrahydro-1,3,2-oxazaphosphorin-2-amine 2-oxide
CAS No. 146452-37-1
项目整合开发状态: Phase II
项目研究机构: Polish Academy of Science (Originator)
...
参考文献标题:Process for the production of the derivs.of 1,3,2-oxazaphosphorinane
文献作者:Kutner,A.; Grynkiewicz,G.; Stec,W.J.; Radzikowski,C.; Szelejeswki,W.; Kinas,R.; Misiura,K.; Grodner,J.; Kusnierczyk,H.; Pilichowska,S.
参考来源:EP 0295576

Thyrsiferyl 23-acetate, TF-23A

Chemical Name: Acetic acid 1-[5(R)-[4-[(2R,4aR,6R,8aS)-6-[5(R)-bromo-2(S),6,6-trimethyltetrahydro-2H-pyran-2-yl]-8a-methyloctahydropyrano[3,2-b]pyran-2-yl}-1(S),4(S)-dihydroxypentyl]-5-methyltetrahydr...
参考文献标题:Total synthesis of tryrsiferyl 23-acetate,a specific inhibitor of protein phosphatase 2A and anti-leukemic inducer of apoptosis
文献作者:Forsyth,G.J.; Gonz醠ez,I.C.
参考来源:J Am Chem Soc 2000,122(38),9099

Thyrsiferol

Chemical Name: 4-[(2R,4aR,6R,8aS)-6-[5(R)-Bromo-2(S),6,6-trimethyltetrahydro-2H-pyran-2-yl]-8a-methyloctahydropyrano[3,2-b]pyran-2-yl]-1-[5(R)-(1-hydroxy-1-methylethyl)-2(R)-methyltetrahydro-2-furanyl...
参考文献标题:Total synthesis of tryrsiferyl 23-acetate,a specific inhibitor of protein phosphatase 2A and anti-leukemic inducer of apoptosis
文献作者:Forsyth,G.J.; Gonz醠ez,I.C.
参考来源:J Am Chem Soc 2000,122(38),9099