Technetium (99mTc) Teboroxime, CDO-MeB, TEBO, TcCl(CDO)3BMe, SQ-30217, CardioTec

Chemical Name: [Bis[(1,2-cyclohexanedione dioximato)(1-)-O][(1,2-cyclohexanedione dioximato)(2-)-O]methylborato(2-)-N,N',N'',N''',N'''',N''''']chloro[99mTc]technetium(III); Chloro[methylboron(1-)tris[1,2-cyclohexanedionedioxime]-N,N',N'',N'''N'''',N'''''][99mTc]technetium; (TPS-7-1-232'4'54)-[Bis[(1,2-cyclohexanedione dioximato)(1-)-O][(1,2-cyclohexanedione dioximato(2-)-O]methylborato(2-)-N,N',N'',N''',N'''',N''''']chlorotechnetium-(99m)Tc
CAS No. 104716-22-5
项目整合开发状态: Registered-1990
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:Tc-99m-teboroxime is prepared by the addition of 370-3700 MBq (10-100 mCi) of Tc-99m pertechnetate (obtained from a Mo-99/Tc-99m generator) to a lyophilized Cardiotec(R) kit,and then heating the kit at 100 C for 15 min.After cooling,Tc-99m-teboroxime is ready for patient administration.The radiochemical purity (RCP) of Tc-99m-teboroxime is consistently greater than 90%; this can be confirmed by paper chromatography.Tc-99m-teboroxime is stable in the kit for at least 6 h following its preparation.Teboroxime (both the Tc-99m and Tc-99 forms) is prepared by template synthesis as shown in the simplified reaction.