项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

U-80271, L-652731

Chemical Name: trans-2,5-Bis(3,4,5-trimethoxyphenyl)tetrahydrofuran
CAS No. 116836-42-1 ((2S-trans)-isomer), 103732-74-7 (racemate)
项目整合开发状态: Preclinical
项目研究机构: Merck & Co. (Originator)
合...
参考文献标题:New 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists
文献作者:Doebber,T.W.; Beattie,T.R.; Shen,T.-Y.; Hwang,S.-B.; Biftu,T.(Merck & Co.,Inc.)
参考来源:AU 8656430; EP 0199324; ES 8801909; JP 1987000077

DQ-2556

Chemical Name: (6R,7R)-7-[2-(2-Aminothiazol-4-yl)-2(Z)-(methoxyimino)acetamido]-3-[4-(5-oxazolyl)pyridinio-1-ylmethyl]-3-cephem-4-carboxylate; [6R-[6alpha,7beta(Z)]]-1-[[7-[[(2-Amino-4-thiazolyl)(meth...
参考文献标题:Cephalosporin derivs.,process for preparing them and pharmaceutical compsns.containing them
文献作者:Furukawa,M.; Tagawa,H.; Hayano,T.; Ejima,A.(Daiichi Pharmaceutical Co.,Ltd.)
参考来源:AU 8541333; EP 0159011; ES 8607319; JP 1985222490; JP 1986007280

Quinocarmycin, Quinocarcin citrate, NSC-601422, KW-2152, DC-52 citrate

Chemical Name: 11-Methoxy-12-methyl-2a,3,4,5,6,6a,7,11b-octahydro-3,6-imino-1H-2-oxa-11c-azanaphth[1,2,3-cd]azulene-5-carboxylic acid citrate salt
CAS No. 101311-75-5
项目整合开发状态: Phase I
项目研究机构...
参考文献标题:Asymmetric synthesis of (-)-quinocarcin
文献作者:Ho,W.B.; Garner,P.; Shin,H.
参考来源:J Am Chem Soc 1992,114(7),2767

Ginkgolide B, BN-52021

Chemical Name: (1S,3S,4R,6aR,7aR,7bR,8S,10aS,11R)-3-tert-Butyl-4,7b,11-trihydroxy-8-methyl-2,3,4,5,7b,8,10a,11-octahydro-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta...
参考文献标题:Total synthesis of (?-ginkgolide B
文献作者:Pace,J.M.; Watterson,S.H.; Nantermet,P.G.; Crimmins,M.T.; Kim-Meade,A.S.; Wagman,A.S.; Thomas,J.B.
参考来源:J Am Chem Soc 1999,121(43),10249

RGH-5981

Chemical Name: 3-Benzyl-2-(nitromethylene)thiazolidine
CAS No. 94776-91-7
项目整合开发状态: Preclinical
项目研究机构: Gedeon Richter (Originator)
合成路线:N-Benzyl 2-aminoethanethiol (I) is reacted with 1,1...
参考文献标题:Thiazolidine derivs.,process for the preparation and pharmaceutical compsns.thereof
文献作者:Dom醤y,G.; Ezer,E.; Harsanyi,K.; Heged黶,B.; Matuz,J.; Pallagi,K.; Szabadkai,I.; Szporny,L.; T閠閚yi,P.(Gedeon Richter Ltd.)
参考来源:BE 0899132; CH 660592; DE 3409801; ES 8604179; FR 2542740; GB 2140412; US 4616025

Org-6370

Chemical Name: dl-11-anti-Dimethylaminebenzo[b]bicyclo[3.3.1]nona-3,6a(10a)-diene hydrochloride; dl-(5alpha,9alpha,11S*)-5,6,9,10-Tetrahydro-N,N-dimethyl-5,9-methanobenzocycloocten-11-amine hydrochlor...
参考文献标题:ORG-6370
文献作者:Pento,J.T.
参考来源:Drugs Fut 1989,14(2),130

Dinimide hydrochloride, PD-113322, NCS D355263, KU 87

Chemical Name: 2-(2-Dimethylaminoethyl)-5,8-dinitro-1H-benz[de] isoquinoline-1,3(2H)-dione monohydrochloride
CAS No. 94985-13-4
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator), University o...
参考文献标题:3,6-Disubstd.-1,8-naphthalimides and methods for their production and use
文献作者:Cheng,C.C.; Zee-Cheng,R.K.-Y.(Pfizer Inc.)
参考来源:EP 0125439; JP 1985001166; US 4499266

Cycloplatam

Chemical Name: (S)-(-)Malatoammine(cyclopentylamine)platinum (II); Ammine(cyclopentanamine)[(S)-hydroxybutanedioato(2-)-O1,O4]platinum
CAS No. 106356-80-3 ((SP-4-3)-isomer), 106356-84-7 ((SP-4-4)-i...
参考文献标题:Carboxylatoplatinum(II) complexes and process for their preparation
文献作者:Cheltsov-Bebutov,P.A.; Kravchenko,A.N.; Schelokov,R.N.; Konovalova,A.L.; Presnov,M.A.; Ivanov,V.B.(Inst.Obs.Neorg.Khim.Imeni; Vse.Onkol.Nauch.Tsentr Ak.)
参考来源:FR 2563524

BM-42304

Chemical Name: 2-[[(E)-2-Methyl-3-phenyl-2-propenyl]hydrazono]propionic acid
CAS No. 97294-25-2
项目整合开发状态: Biological Testing
项目研究机构: Roche (Originator)
合成路线:By condensation of N-(2-methyl-...
参考文献标题:BM-42304
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1986,11(3),173

R-61837

Chemical Name: 3-Methoxy-6-[4-(3-methylphenyl)-1-piperazinyl]pyridazine
CAS No. 100241-46-1
项目整合开发状态: Phase II
项目研究机构: Janssen (Originator)
合成路线:N-Alkylation of 1-(3-methylphenyl)piperazin...
参考文献标题:R 61837
文献作者:Andries,K.; Stokbroekx,R.
参考来源:Drugs Fut 1990,15(3),237