Cycloplatam

Chemical Name: (S)-(-)Malatoammine(cyclopentylamine)platinum (II); Ammine(cyclopentanamine)[(S)-hydroxybutanedioato(2-)-O1,O4]platinum
CAS No. 106356-80-3 ((SP-4-3)-isomer), 106356-84-7 ((SP-4-4)-isomer), 106283-21-0 ([SP-4-3-(S)]-isomer), 106356-83-6 ([SP-4-4(S)]-isomer), 109837-67-4 (undefined isomer)
项目整合开发状态: Phase II
项目研究机构: Inst. Obs. Neorg. Khim. Imeni (Originator), Russian Academy of Medical Sciences (Originator), Vse. Onkol. Nauch. Tsentr Ak. (Originator)
合成路线:Treatment of cyclopentylamine (I) with potassium trichloroaminoplatinate and potassium iodide in H2O provides a mixture of platinum complexes (II) and (III),which is then subjected to reaction with silver (S)-(-)-malate (IV) in H2O to furnish the desired platinum complex.