Trombodipine, PCA-4230
Chemical Name: 2,4,6-Trimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid 2-(1,1-dioxido-3-oxo-2,3-dihydro-1,2-benzisothiazol-2-yl)ethyl ethyl diester
CAS No. 113658-85-8
项目整合开发状态: Phase II
项目研究机构: Alter (Originator)
合成路线:The reaction between acetaldehyde (I),ethyl 3-aminocrotonate (II) and acetoacetate (III) in ethanolic medium yields the corresponding 1,4-dihydropyridine.
📌 参考资料/链接：
参考文献标题:1,4-Dihydropyridines,processes for their preparation and their use as antithrombotic drugs
文献作者:Sunkel,C.; Fau de Casa-Juana,M.; Dorrego,F.; Priego,J.; Ortega,P.; Cillero,J.(Alter SA)
参考来源:DE 3617976; EP 0253092; US 4782069
📄 详细内容
合成路线:The reaction between acetaldehyde (I),ethyl 3-aminocrotonate (II) and acetoacetate (III) in ethanolic medium yields the corresponding 1,4-dihydropyridine.
参考文献标题:Trombodipine
文献作者:Ortega,M.P.; Priego,J.G.; Fau de Casa-Juana,M.; Cillero,F.J.; Sunkel,C.E.
参考来源:Drugs Fut 1992,17(6),465
产品链接: CAS No. 113658-85-8››