Cerebrocrast, IOS-1.1212
Chemical Name: 4-[2-(Difluoromethoxy)phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid di(2-propoxyethyl) diester
CAS No. 108863-62-3
项目整合开发状态: Phase I
项目研究机构: Latvian Institute of Organic Synthesis (Originator)
合成路线:Cerebrocrast is prepared in Hantzsch-type reaction from 2-(propoxy)ethyl acetoacetate (III),2-(difluoromethoxy)benzaldehyde and ammonia,or from 2-(propoxy)ethyl beta-aminocrotonate (IV) and 2-(difluoromethoxy)benzaldehyde.The necessary raw material,2-(propoxy)ethyl acetoacetate (III),is prepared from 2-(propoxy)ethanole (II) by acetoacetylation with diketene (I).
📌 参考资料/链接：
参考文献标题:Alkoxy- and phenoxy-alkyl esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid
文献作者:Makarova,N.V.; Biseniex,E.A.; Uldrikis,Y.R.; Dubur,G.Y.; Veveris,M.M.; Kimenis,A.A.(Latvian Institute of Organic Synthesis)
参考来源:FR 2587701
📄 详细内容
合成路线:Cerebrocrast is prepared in Hantzsch-type reaction from 2-(propoxy)ethyl acetoacetate (III),2-(difluoromethoxy)benzaldehyde and ammonia,or from 2-(propoxy)ethyl beta-aminocrotonate (IV) and 2-(difluoromethoxy)benzaldehyde.The necessary raw material,2-(propoxy)ethyl acetoacetate (III),is prepared from 2-(propoxy)ethanole (II) by acetoacetylation with diketene (I).
参考文献标题:Synthesis and selective vasodilating properties of esters of 2,6-dimethyl-4-(2-difluoromethoxyphenyl)-1,4-dihydropyridine-3,4-dicarboxylic acid
文献作者:Dubur,G.J.; Veveris,M.M.; Weinheimer,G.; Bisenieks,E.A.; Makarova,N.V.; Kimenis,A.A.; Uldrikis,J.R.; Lukevics,E.J.; Dooley,D.; Osswald,H.
参考来源:Arzneim-Forsch Drug Res 1989,39(10),1185-9
合成路线:Cerebrocrast is prepared in Hantzsch-type reaction from 2-(propoxy)ethyl acetoacetate (III),2-(difluoromethoxy)benzaldehyde and ammonia,or from 2-(propoxy)ethyl beta-aminocrotonate (IV) and 2-(difluoromethoxy)benzaldehyde.The necessary raw material,2-(propoxy)ethyl acetoacetate (III),is prepared from 2-(propoxy)ethanole (II) by acetoacetylation with diketene (I).
参考文献标题:Cerebrocrast
文献作者:Klusa,V.
参考来源:Drugs Fut 1995,20(2),135
产品链接: CAS No. 108863-62-3››