Elliprabin, Ellipravin, SUN-4599
Chemical Name: 9-Hydroxy-5,11-dimethyl-2-(3alpha,4beta,5beta-trihydroxytetrahydropyran-2beta-yl)-6H-pyrido[4,3-b]-carbazolium bromide; 9-Hydroxy-5,11-dimethyl-2-(alpha-L-arabinopyranosyl)-6H-pyrido[4,3-b]carbazolium bromide; 9-Hydroxy-2-(alpha-L-arabinopyranosyl)ellipticinium bromide
CAS No. 103461-20-7
项目整合开发状态: Phase II
项目研究机构: Daiichi Suntory Pharma (Originator)
合成路线:The condensation of 9-acetoxyellipticine (I) with 2,3,4-tri-O-acetyl-beta-L-arabinopyranosyl bromide (II) by means of CdCO3 in refluxing nitromethane gives the corresponding tetraacetoxy derivative (III),which is then deprotected by treatment with dry ammonia in methanol.
📌 参考资料/链接：
参考文献标题:Ellipticine derivs.
文献作者:Honda,T.; Nakanishi,T.(Suntory Ltd.)
参考来源:AU 8545252; EP 0173462; JP 1986037799; JP 1987022794; JP 1987022795; JP 1987030795; US 4698423
📄 详细内容
合成路线:The condensation of 9-acetoxyellipticine (I) with 2,3,4-tri-O-acetyl-beta-L-arabinopyranosyl bromide (II) by means of CdCO3 in refluxing nitromethane gives the corresponding tetraacetoxy derivative (III),which is then deprotected by treatment with dry ammonia in methanol.
参考文献标题:ELLIPRAVIN
文献作者:Hoshi,A.; Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(2),116
合成路线:The condensation of 9-acetoxyellipticine (I) with 2,3,4-tri-O-acetyl-beta-L-arabinopyranosyl bromide (II) by means of CdCO3 in refluxing nitromethane gives the corresponding tetraacetoxy derivative (III),which is then deprotected by treatment with dry ammonia in methanol.
参考文献标题:Synthesis and antitumor activity of quaternary ellipticine glycosides,a series of novel and highly active antitumor agents
文献作者:Honda,T.; Kato,M.; Inoue,M.; Shimamoto,T.; Shima,K.; Nakanishi,T.; Yoshida,T.; Noguchi,T.
参考来源:J Med Chem 1988,31(7),1295-305