项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

LY-186826

Chemical Name: 3-Acetyl-7-[2-(2-aminothiazol-4-yl)-2(Z)-(methoxyimino)acetamido]-8-oxo-1,5-diazabicyclo[3.3.0]oct-2-ene-2-carboxylic acid
CAS No. 106972-85-4
项目整合开发状态: Preclinical
项目研究机构: Lil...
参考文献标题:BICYCLIC PYRAZOLIDINONE ANTIBACTERIAL AGENTS
文献作者:Jungheim,L.N.; Ternansky,R.J.; Holmes,R.E.
参考来源:Drugs Fut 1990,15(2),149

NCQ-318

Chemical Name: (S)-(-)-2-Amino-3-bromo-N-[(1-ethyl-2-pyrrolidin- yl)methyl]-5,6-dimethoxybenzamide
CAS No. 101460-34-8
项目整合开发状态: Biological Testing
项目研究机构: AstraZeneca (Originator)
合成路线:Th...
参考文献标题:Novel substituted salicylamides and benzamides as selective dopamine D2-receptor antagonists
文献作者:H鰃berg,M.
参考来源:Drugs Fut 1991,16(4),333

AM-682

Chemical Name: 2-[(4-Carboxybenzoyl)amino]-4-[(1-oxopropyl)amino]benzoic acid 1-ethyl ester sodium salt; Ethyl 2-(4-carboxybenzamido)-4-propionamidobenzoate sodium salt
CAS No. 73625-86-2 (free aci...
参考文献标题:AM-682
文献作者:Tasaka,K.
参考来源:Drugs Fut 1989,14(8),738

ME-2303, FAD-104

Chemical Name: 7-O-(2,6-Dideoxy-2-fluoro-alpha-L-talopyranosyl)pimelyladryamycinone; (8S,10S)-8-(6-Carboxyhexanoyloxyacetyl)-10-[(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl)oxy]-7,8,9,10-tetrahydro-6,...
参考文献标题:Novel anthracycline derivs.,a process for preparing them and their use as medicaments
文献作者:Umezawa,H.; Umezawa,S.; Tsuchiya,T.; Takeuchi,T.; Takagi,Y.; Yoneda,T.; Fukatsu,S.(Microbial Chemistry Research Foundation)
参考来源:EP 0275431; JP 1988141992

AHR-5333B

Chemical Name: 1-[4-[3-[4-Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone alpha-hydroxybenzeneacetate (1:1)
CAS No. 60284-71-1 (free base)
项目整合开发状态: Phase I
...
参考文献标题:AHR-5333B
文献作者:Yanni,J.M.; Walsh,D.A.
参考来源:Drugs Fut 1988,13(7),605

Fluasterone, HE-2500, 8354

Chemical Name: 16alpha-Fluoroandrost-5-en-17-one
CAS No. 112859-71-9
项目整合开发状态: Phase II
项目研究机构: Temple University (Originator), Aeson Therapeutics (Licensee), Hollis-Eden (Licensee)
合成路线:B...
参考文献标题:Steroids useful as anti-cancer and anti-obesity agents,a therapeutic compsn.containing them and use thereof for the preparation of a therapeutic compsn.
文献作者:Lewbart,M.L.; Schwartz,A.G.(Research Corporation Technologies,Inc.)
参考来源:EP 0246650; JP 1987283993

E-90/007, KW-2149, KT-6149

Chemical Name: 7-N-[2-[[2-(gamma-L-Glutamylamino)ethyl]dithio]ethyl]mitomycin C; (1aalpha,8balpha)-8beta-(Carbamoyloxymethyl)-6-[2-[2-(gamma-L-glutamylamino)ethyldithio]ethylamino]-8aalpha-methoxy-5-m...
参考文献标题:Mitomycin derivs.
文献作者:Kono,M.; Saito,Y.; Kanda,Y.; Kasai,M.; Sato,A.; Morimoto,M.; Ashizawa,T.(Kyowa Hakko Kogyo Co.,Ltd.)
参考来源:EP 0280741; JP 1988505196; US 5103018; WO 8801622

D-11208

Chemical Name: N-[2-Amino-6-(4-trifluoromethylbenzylamino)pyridin-3-yl]carbamic acid ethyl ester hydrochloride; 2-Amino-3-ethoxycarbonylamino-6-(4-trifluoromethylbenzylamino)pyridine hydrochloride
...
参考文献标题:2-Amino-3-acylamino-6-benzylaminopyridine derivatives having antiepileptic action
文献作者:Bebengurg,W.; Engek,J.; Heese,J.; Thiele,K.(Degussa AG)
参考来源:DE 3337593

Lobuprofen hydrochloride

Chemical Name: 2-[4-(m-Chlorophenyl)-1-piperazinyl]ethyl (?-p-isobutylhydratropate hydrochloride; (?-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid 2-[4-(3-chlorophenyl)-1-piperazinyl]ethyl ester h...
参考文献标题:Novel phenylpiperazine derivs.,process for prepar
文献作者:Alamo Gonzalez,C.; Carretero Colon,J.M.; Martin Jimenez,J.L.(Juste,SA Qu韒ico-Farmac閡tica)
参考来源:EP 0141884

TMA-230

Chemical Name: (+)-(5R,6S)-6-[1(R)-Hydroxyethyl]-2-(3-pyridyl)-2-penem-3-carboxylic acid acetoxymethyl ester
CAS No. 113141-80-3
项目整合开发状态: Phase II
项目研究机构: Novartis (Originator), Takeda (Lice...
参考文献标题:2-Pyridyl-penem cpds
文献作者:Lang,M.(Novartis AG)
参考来源:EP 0246187; JP 1987263183; US 4826832