合成路线:The condensation of (XII) with monosodium pimelate (XIII) in acetone - water yields the protected hemipimelate (XIV),which is finally treated with hot acetic acid - water.
参考文献标题:Synthesis and antitumor activities of 14-O-acyl derivatives of 7-O-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl)adriamycin
文献作者:Tsuchiya,T.; Takagi,Y.; Umezawa,S.; Takeuchi,T.; Komuro,K.; Nosaka,C.; Umezawa,H.; Fukatsu,S.; Yoneta,T.
参考来源:J Antibiot 1988,41(7),988-91
合成路线:L-Fucose (I) is converted successively to its methyl glucoside (II),the 3,4-O-isopropylidene derivative (III),the 2-O-acetyl derivative (IV),the 2-O-acetyl-L-methylfucoside (V),the tosylate (VI),the 4-O-benzyl derivative (VII) and finally,through various steps,the 3,4-O-diacetyl-2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl bromide (VIII).The condensation of (VIII) with daunomycinone (IX) gives the daunomycin derivative (X),which is converted to the isopropylidene derivative (XI).The bromination of (XI) affords the bromo derivative (XII).
合成路线:The condensation of (XII) with monosodium pimelate (XIII) in acetone - water yields the protected hemipimelate (XIV),which is finally treated with hot acetic acid - water.
参考文献标题:Biological properties of ME2303 (FAD-104),a new anthracycline
文献作者:Omoto,S.; Kondo,S.; Fukatsu,S.; Takeuchi,T.; Umezawa,K.; Tsuchiya,T.; Umezawa,S.
参考来源:Drug Exp Clin Res 1988,14(7),435-9
合成路线:L-Fucose (I) is converted successively to its methyl glucoside (II),the 3,4-O-isopropylidene derivative (III),the 2-O-acetyl derivative (IV),the 2-O-acetyl-L-methylfucoside (V),the tosylate (VI),the 4-O-benzyl derivative (VII) and finally,through various steps,the 3,4-O-diacetyl-2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl bromide (VIII).The condensation of (VIII) with daunomycinone (IX) gives the daunomycin derivative (X),which is converted to the isopropylidene derivative (XI).The bromination of (XI) affords the bromo derivative (XII).
合成路线:The condensation of (XII) with monosodium pimelate (XIII) in acetone - water yields the protected hemipimelate (XIV),which is finally treated with hot acetic acid - water.
参考文献标题:ME2303
文献作者:Hoshi,A.; Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(8),756
产品链接: CAS No. 116521-53-0››