项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

L-659989

Chemical Name: (?-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran
CAS No. 113787-28-3, 106331-88-8 (trans-enantiomers mixture)
项目整合开发状态: Preclinica...
参考文献标题:(?-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (L-659,989),a novel,potent PAF receptor antagonist
文献作者:Ponpipom,M.M.; Hwang,S.B.; Doebber,T.W.; Acton,J.J.; Alberts,A.W.; Biftu,T.; Brooker,D.R.; Bugianesi,R.L.; Chabala,J.C.; Gamble,N.L.; et al.
参考来源:Biochem Biophys Res Commun 1988,150(3),1213

Iododihydrorhodamine 123, Iodo-reduced Rhodamine 123

Chemical Name: 2-(3',6'-Diamino-2'-iodo-9H-xanthen-9'-yl)benzoic acid methyl ester
CAS No. 109244-59-9, 109244-63-5 (125I-labeled)
项目整合开发状态: Biological Testing
项目研究机构: Harvard College (Origin...
参考文献标题:Iodo-reduced Rhodamine 123
文献作者:Kassis,A.I.; Kinsey,B.M.
参考来源:Drugs Fut 1988,13(9),825

SDZ-87-469

Chemical Name: (E)-3-Chloro-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methylbenzo[b]thiophene-7-methanamine hydrochloride
CAS No. 87906-33-0, 87906-31-8 (free base), 87906-32-9 (Z-isomer, free base)
项目...
参考文献标题:New allylamines and their use.
文献作者:Stz,A.(Novartis Deutschland GmbH)
参考来源:DE 3302814

Nebracetam fumarate, WEB-1881-FU-y [as((+)-enantiomer), WEB-1881-FU-X [as((-)-enantiomer), WEB-1881-FU, Memolog

Chemical Name: (?-4-(Aminomethyl)-1-benzylpyrrolidin-2-one hemifumarate
CAS No. 142116-35-6 ((-)-enantiomer), 103295-62-1 ((-)-enantiomer, free base), 142116-34-5 ((+)-enantiomer), 103295-65-4 ((+)...
参考文献标题:Prostaglandins of the F series
文献作者:Ueno,R.; Oda,T.(Ueno Fine Chemicals Industry,Ltd.)
参考来源:EP 0289349; JP 1989151552; US 5001153; US 5106869

FLB-463

Chemical Name: (S)-(-)-3-Bromo-N-(1-ethyl-2-pyrrolidinylmethyl)-2-hydroxy-5,6-dimethoxybenzamide
CAS No. 101460-66-6, 125198-22-3 (mesylate salt)
项目整合开发状态: Preclinical
项目研究机构: AstraZeneca (Or...
参考文献标题:Potential antipsychotic agents.5.Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds
文献作者:H鰃berg,T.; et al.
参考来源:J Med Chem 1990,331155-63

MDL-27695

Chemical Name: 1,19-Diphenyl-2,6,14,18-tetraazanonadecane tetrahydrochloride; N,N'-Bis[3-(benzylamino)propyl]-1,7-diaminoheptane tetrahydrochloride; 1,17-Bis(phenylmethyl)-1,5,13,17-tetraazaheptadecan...
参考文献标题:MDL 27,695
文献作者:Baumann,R.J.; Bitonti,A.J.; Edwards,M.L.
参考来源:Drugs Fut 1991,16(10),908

Technetium (99mTc) bicisate, Technetium Tc99m bicisate, RP-217(diHCl), ECD-[99mTc], [99mTc]-ECD, Neurolite

Chemical Name: (SP-5-35)-[[Diethyl-N,N'-1,2-ethanediylbis[L-cysteinato]](3-)-N,N',S,S']oxotechnetium(99m)Tc; [N,N'-Ethylenedi-L-cysteinato(3-)]oxo[99mTc]technetium(V) diethyl ester
CAS No. 121281-4...
参考文献标题:Ester-substd.diaminedithiols and radiolabeled complexes thereof
文献作者:Bergstein,P.L.; Cheesman,E.H.; Watson,A.D.(DuPont Pharmaceuticals Co.)
参考来源:AU 8811748; EP 0279417; JP 1988285549

Abbott-49816, A-49816

Chemical Name: Ethyl [2,3-dichloro-4-(3-aminomethyl-4-hydroxybenzoyl)phenoxy]acetate hydrochloride
CAS No. 78235-46-8, 78235-72-0 (free base)
项目整合开发状态: Clinical
项目研究机构: Abbott (Originator) 参考文献标题:A-49816
文献作者:Luther,R.R.; Plattner,J.J.
参考来源:Drugs Fut 1988,13(12),1039

GR-63116, M-14659

Chemical Name: (7R,8R)-7beta-[2-(2-Aminothiazol-4-yl)-2-[(S)-carboxy-(3,4-dihydroxyphenyl)methoxyimino)acetamido]-3-(2-carboxy-5-methyl-s-triazolo[1,5-a]pyrimidin-7-ylthiomethyl)-3-cephem-4-carboxylic...
参考文献标题:Cephalosporin derivs.
文献作者:Ohnishi,H.; Kosuzume,H.; Mizota,M.; Suzuki,Y.; Mochida,E.(Mochida Pharmaceutical Co.,Ltd.)
参考来源:AU 8654876; AU 8655860; EP 0197409; EP 0359291; JP 1987077392; JP 1987161793; JP 1987167784; US 4840945; US 5001121; WO 8605786

SQ-30741

Chemical Name: [1S-(1beta,2alpha(5Z),3alpha,4beta)]-7-[3-[[[[(1-Oxoheptyl)amino]acetyl]amino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid
CAS No. 107332-47-8
项目整合开发状态: Phase II
项目研究...
参考文献标题:Synthesis and in vitro pharmacology of 7-oxabicyclo[2.2.1]heptane analogues of thromboxane A2/PGH2
文献作者:Gougoutas,J.Z.; Sprague,P.W.; Harris,D.N.; Malley,M.F.; Heikes,J.E.; Greenberg,R.
参考来源:J Med Chem 1985,281580-1590