MDL-27695
Chemical Name: 1,19-Diphenyl-2,6,14,18-tetraazanonadecane tetrahydrochloride; N,N'-Bis[3-(benzylamino)propyl]-1,7-diaminoheptane tetrahydrochloride; 1,17-Bis(phenylmethyl)-1,5,13,17-tetraazaheptadecane tetrahydrochloride
CAS No. 131275-14-4, 117654-71-4 (free base)
项目整合开发状态: Preclinical
项目研究机构: Aventis Pharma (Originator)
合成路线:Reaction of 1,7-diaminoheptane with acrylonitrile gives the dinitrile (II).Reduction of the nitrile functionality yields the tetraamine (III).Reductive alkylation gives the dibenzyltetraamine MDL 27,695.
📌 参考资料/链接：
参考文献标题:MDL 27,695
文献作者:Baumann,R.J.; Bitonti,A.J.; Edwards,M.L.
参考来源:Drugs Fut 1991,16(10),908
📄 详细内容
合成路线:Reaction of 1,7-diaminoheptane with acrylonitrile gives the dinitrile (II).Reduction of the nitrile functionality yields the tetraamine (III).Reductive alkylation gives the dibenzyltetraamine MDL 27,695.
参考文献标题:Antimalarial polyamine analogs
文献作者:Dumont,J.A.; Stemerick,D.M.; Sjoerdsma,A.; McCann,P.P.; Edwards,M.L.; Bitonti,A.J.
参考来源:J Med Chem 1991,34(2),569-74
产品链接: CAS No. 131275-14-4›› 产品链接: CAS No.117654-71-4››