合成路线:This compound can be prepared by two different ways:1) The dehydration of 2-amino-2-methylpropranol (I) with H2SO4 at 170-200 C gives 2,2-dimethylazirine (II),which by reaction with methanol by means of boron trifluoride - methanol complex and fractional distillation affords 2-methoxy-2-methylpropylamine (III).The reaction of (III) with formic acid in acetic anhydride yields N-(2-methoxy-2-methylpropyl)formamide (IV),which by reaction with diphosgene (trichloromethyl chloroformate) and triethylamine in dichloromethane gives 2-methoxy-2-methylpropylisonitrile (MIBI) (V).Finally,this compound or its CuBF4 complex Cu(MIBI)4BF4 is treated with 99mTcO4 (VI) and sodium dithionite or formamide sulfinic acid respectively,in ethanol - water.2) The methylation of methyl 2-hydroxyisobutylrate (VII) with NaH - methyl iodide in DMF - THF gives methyl 2-methoxy-2-methylpropanoate (VIII),which by reaction with ammonia is converted to the corresponding amide (IX).Finally,this compound is reduced with LiAlH4 in THF yielding the amine (III),already obtained.
参考文献标题:Myocardial kinetics of technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile
文献作者:Williams,S.; Okada,R.D.; Gaffney,T.; Glover,D.
参考来源:Circulation 1988,77491
合成路线:This compound can be prepared by two different ways:1) The dehydration of 2-amino-2-methylpropranol (I) with H2SO4 at 170-200 C gives 2,2-dimethylazirine (II),which by reaction with methanol by means of boron trifluoride - methanol complex and fractional distillation affords 2-methoxy-2-methylpropylamine (III).The reaction of (III) with formic acid in acetic anhydride yields N-(2-methoxy-2-methylpropyl)formamide (IV),which by reaction with diphosgene (trichloromethyl chloroformate) and triethylamine in dichloromethane gives 2-methoxy-2-methylpropylisonitrile (MIBI) (V).Finally,this compound or its CuBF4 complex Cu(MIBI)4BF4 is treated with 99mTcO4 (VI) and sodium dithionite or formamide sulfinic acid respectively,in ethanol - water.2) The methylation of methyl 2-hydroxyisobutylrate (VII) with NaH - methyl iodide in DMF - THF gives methyl 2-methoxy-2-methylpropanoate (VIII),which by reaction with ammonia is converted to the corresponding amide (IX).Finally,this compound is reduced with LiAlH4 in THF yielding the amine (III),already obtained.
参考文献标题:TECHNETIUM [(99m)Tc] SESTAMIBI < Prop INN; BAN >
文献作者:Carrell,S.A.; Robinson,C.P.; Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(12),1169
产品链接: CAS No. 109581-73-9››