项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Moxonidine hydrochloride hydrate, LY-326869, BE-5895, BDF-5895, Norcynt, Nucynt, Moxon, Normoxin, Physiotens, Lomox, Cynt

莫索尼定Chemical Name: 4-Chloro-5-(2-imidazolin-2-ylamino)-6-methoxy-2-methylpyrimidine hydrochloride hydrate
CAS No. 75438-57-2 (free base)
项目整合开发状态: Launched-1991
项目研究机构: Beiersdorf (Originator...
参考文献标题:Novel remedy for peptic ulcer
文献作者:Mutsumi,M.(Nippon Chemiphar Co.,Ltd.)
参考来源:JP 1982075920

Murocainide, MD-750819(HCl)

莫罗卡尼Chemical Name: 4,7-Dimethoxy-5-N-methylcarbamoylamino-6-[2-(N-piperidino)ethoxy]benzofuran; N-[4,7-Dimethoxy-6-[2-(1-piperidinyl)ethoxy]-5-benzofuranyl]-N'-methylurea
CAS No. 66203-94-9
项目整合...
参考文献标题:Novel aminoalkoxybenzofurans,their process of preparation and their therapeutic use
文献作者:Bourgery,G.; Lacour,A.; Pourrias,B.; Bregeon,G.C.(Laboratoires Delalande)
参考来源:FR 2358143

Monatepil maleate, AJ-2615, AD-2615(former code)

莫那匹尔马来酸盐莫那匹尔Chemical Name: (?-N-(6,11-Dihydrodibenzo[b,e]thiepin-11-yl)-4-[4-(4-fluorophenyl)piperazin-1-yl]butyramide maleate
CAS No. 103379-03-9, 132046-06-1 (deleted CAS), 132019-54-6 (free base...
参考文献标题:A new class of calcium antagonists.2.Synthesis and biological activity of 11-[[4-[4-(4-fluorophenyl)-1-piperazinyl]butyryl]amino]-6,11-dihydrodibenzo[b,e]thiepin maleate and related compounds
文献作者:Honda,Y.; Naruto,S.; Hatano,N.; Yoshida,T.; Kurokawa,M.; Uno,H.; Sato,F.; Fujiwara,I.; Matsumoto,J.-I.
参考来源:J Med Chem 1991,34(3),927-34

Mofezolac, N-22, Disopain

莫非佐酸Chemical Name: 3,4-Bis(4-methoxyphenyl)-5-isoxazoleacetic acid; 3,4-Di-(p-methoxyphenyl)isoxazole-5-acetic acid
CAS No. 78967-07-4
项目整合开发状态: Launched-1994
项目研究机构: Mitsubishi Pharma (Origi...
参考文献标题:3,4-Diaryl-5-acetic acid cpds.,process for prepar
文献作者:Micetich,R.G.; Shaw,C.-C.; Rastogi,R.B.(CDC Life Sciences Inc.)
参考来源:EP 0026928; US 4327222

Mofegiline hydrochloride, MDL-72974A

莫非吉兰莫非吉兰 Chemical Name: (E)-3-Fluoro-2-[2-(4-fluorophenyl)ethyl]allylamine hydrochloride; (E)-4-Fluoro-beta-(fluoromethylene)benzenebutanamine hydrochloride
CAS No. 120635-25-8, 119386-96-8 (free ...
参考文献标题:MDL-72,974A
文献作者:McDonald,I.A.; Bey,P.; Zreika,M.; Palfreyman,M.G.
参考来源:Drugs Fut 1991,16(5),428

Phaseolinone

菜豆壳孢酮Chemical Name: 3(S),4(R)-Epoxy-6(R)-hydroxy-3-[2-(hydroxymethyl)oxiran-2-yl]-4a(S),5(R)-dimethyl-2,3,4,4a,5,6,7,8-octahydronaphthalen-2-one
CAS No. 85431-61-4
项目整合开发状态: Preclinical
项目研究机...
参考文献标题:Synthesis of oxygenated morphilanes,gigantone phomenone and phaseolinone,phytotoxins from pathogenic fungi
文献作者:Kitahara,T.; Kurata,H.; Mori,K.; Kiyoto,H.
参考来源:Tetrahedron 1991,1649-54

Nabumetone, BRL-14777, Nabuser, Listran, Relafen, Relifen, Arthaxan, Relifex

萘丁美酮Chemical Name: 4-(6-Methoxy-2-naphthalenyl)-2-butanone
CAS No. 42924-53-8
项目整合开发状态: Launched-1985
项目研究机构: GlaxoSmithKline (Originator), Procter & Gamble (Not Determined), Meda (Licensee),...
参考文献标题:1-(p-Methoxy-p-hydroxy,and p-benzyloxybenzoyl)-2-pyrrolidinones
文献作者:Kyburz,E.; Aschwanden,W.(F.Hoffmann-La Roche AG)
参考来源:DD 141828; EP 0005143; EP 0044088; ES 477587; ES 483756; JP 54117468

Aclatonium napadisilate, TM-723, Abovis

萘二磺酸乙乳胆铵Chemical Name: Bis[2-(2-acetoxypropionyloxy)-N,N,N-trimethylethanaminium] 1,5-naphthalenedisulfonate
CAS No. 55077-30-0
项目整合开发状态: Launched
项目研究机构: Toyama (Originator)
合成路线:The reac...
参考文献标题:Aclatonium Napadisilate
文献作者:Castar,J.; Prous,J.
参考来源:Drugs Fut 1982,7(4),227

Nafimidone hydrochloride, RS-81943

萘咪酮萘咪酮 Chemical Name: 2-Imidazol-1-yl-2'-acetonaphthone hydrochloride; 1-(2-Naphthoylmethyl)imidazole hydrochloride; 2-(1H-Imidazol-1-yl)-1-(2-naphthalenyl)ethanone hydrochloride
CAS No. 70891-37...
参考文献标题:1-(Naphthylethyl)imidazole derivs.,their preparation,and pharmaceutical compsns.containing them
文献作者:Walker,K.A.M.(Syntex (USA),Inc.)
参考来源:EP 0001926

Naftopidil, KT-611, BM-15275, Avishot, Flivas

萘哌地尔Chemical Name: (?-1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)-2-propanol
CAS No. 57149-07-2
项目整合开发状态: Launched-1999
项目研究机构: Roche (Originator), Organon (Not Determined), Asahi...
参考文献标题:1-[3-(Napht-1-yloxy)-2-hydroxypropyl]-piperazine c
文献作者:Thiel,M.; Sponer,G.; Stach,K.; Witte,E.-C.; Roesch,E.(Roche Diagnostics GmbH)
参考来源:GB 1445548; US 3997666