Naftopidil, KT-611, BM-15275, Avishot, Flivas
萘哌地尔Chemical Name: (?-1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)-2-propanol
CAS No. 57149-07-2
项目整合开发状态: Launched-1999
项目研究机构: Roche (Originator), Organon (Not Determined), Asahi Kasei (Licensee)
合成路线:The reaction of 1-naphthol (I) with epichlorohydrin (II) in the presence of aqueous sodium hydroxide yields 1-(1-naphthyloxy)-2,3-epoxypropane (III).(III) is then reacted either in alcohol or without any solvent with 1-(2-methoxyphenyl)piperazine (IV).
📌 参考资料/链接：
参考文献标题:1-[3-(Napht-1-yloxy)-2-hydroxypropyl]-piperazine c
文献作者:Thiel,M.; Sponer,G.; Stach,K.; Witte,E.-C.; Roesch,E.(Roche Diagnostics GmbH)
参考来源:GB 1445548; US 3997666
📄 详细内容
合成路线:The reaction of 1-naphthol (I) with epichlorohydrin (II) in the presence of aqueous sodium hydroxide yields 1-(1-naphthyloxy)-2,3-epoxypropane (III).(III) is then reacted either in alcohol or without any solvent with 1-(2-methoxyphenyl)piperazine (IV).
参考文献标题:Naftopidil
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1987,12(1),31
产品链接: CAS No. 57149-07-2››