Nafimidone hydrochloride, RS-81943
萘咪酮 萘咪酮 Chemical Name: 2-Imidazol-1-yl-2'-acetonaphthone hydrochloride; 1-(2-Naphthoylmethyl)imidazole hydrochloride; 2-(1H-Imidazol-1-yl)-1-(2-naphthalenyl)ethanone hydrochloride
CAS No. 70891-37-1, 64212-22-2 (free base), 64212-23-3 (mononitrate)
项目整合开发状态: Phase I
项目研究机构: Roche Bioscience (Originator)
合成路线:By reaction of 2-naphthyl bromomethyl ketone (I) with imidazole (II) in DMF,followed by a treatment with HCl in ether.
📌 参考资料/链接：
参考文献标题:1-(Naphthylethyl)imidazole derivs.,their preparation,and pharmaceutical compsns.containing them
文献作者:Walker,K.A.M.(Syntex (USA),Inc.)
参考来源:EP 0001926
📄 详细内容
合成路线:By reaction of 2-naphthyl bromomethyl ketone (I) with imidazole (II) in DMF,followed by a treatment with HCl in ether.
参考文献标题:Imidazole derivs.,their preparation and their use in pharmaceutical compsns.
文献作者:Walker,K.A.M.(Syntex (USA),Inc.)
参考来源:EP 0013786
合成路线:By reaction of 2-naphthyl bromomethyl ketone (I) with imidazole (II) in DMF,followed by a treatment with HCl in ether.
参考文献标题:Nafimidone hydrochloride
文献作者:Serradell,M.N.; Blancafort,P.; Castar,J.
参考来源:Drugs Fut 1983,8(8),689
合成路线:By reaction of 2-naphthyl bromomethyl ketone (I) with imidazole (II) in DMF,followed by a treatment with HCl in ether.
参考文献标题:1-(Naphthylalyl)-1H-imidazole derivatives,a new class of anticonvulsant agents
文献作者:Walker,K.A.M.; Wallach,M.B.; Hirschfeld,D.R.
参考来源:J Med Chem 1981,24(1),67
合成路线:By reaction of 2-naphthyl bromomethyl ketone (I) with imidazole (II) in DMF,followed by a treatment with HCl in ether.
参考文献标题:
文献作者:Walker,K.A.M.
参考来源:GB 1540023