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项目整合精选>>>Moxonidine hydrochloride hydrate, LY-326869, BE-5895, BDF-5895, Norcynt, Nucynt, Moxon, Normoxin, Physiotens, Lomox, Cynt
Moxonidine hydrochloride hydrate, LY-326869, BE-5895, BDF-5895, Norcynt, Nucynt, Moxon, Normoxin, Physiotens, Lomox, Cynt
莫索尼定Chemical Name: 4-Chloro-5-(2-imidazolin-2-ylamino)-6-methoxy-2-methylpyrimidine hydrochloride hydrate
CAS No. 75438-57-2 (free base)
项目整合开发状态: Launched-1991
项目研究机构: Beiersdorf (Originator), Il-Yang (Licensee), Lilly (Licensee), Recordati (Licensee), Solvay (Licensee)
合成路线:The condensation of 5-amino 2 methyl 4,6-dichloropyrimidine (I) with 1-acetyl-2-imidazolin-2-one (II) by means of POCl3 at 50 C gives 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-ylamino)pyrimidine (III),which is then methoxylated and desacetylated by treatment with sodium methoxide in refluxing methanol.
📌 参考资料/链接：
参考文献标题:Novel remedy for peptic ulcer
文献作者:Mutsumi,M.(Nippon Chemiphar Co.,Ltd.)
参考来源:JP 1982075920
📄 详细内容
合成路线:The condensation of 5-amino 2 methyl 4,6-dichloropyrimidine (I) with 1-acetyl-2-imidazolin-2-one (II) by means of POCl3 at 50 C gives 4,6-dichloro-2-methyl-5-(1-acetyl-2-imidazolin-2-ylamino)pyrimidine (III),which is then methoxylated and desacetylated by treatment with sodium methoxide in refluxing methanol.
参考文献标题:Moxonidine hydrochloride
文献作者:Mannhold,R.
参考来源:Drugs Fut 1987,12(6),553
产品链接: CAS No. 75438-57-2››