项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Bryostatin 1, BMY-45618, NSC-339555

藓苔抑制素 1Chemical Name: 7beta-Acetoxy-5beta,9beta:11beta,15beta:19alpha,23alpha-triepoxy-3alpha,9alpha,19beta-trihydroxy-25beta-[1(R)-hydroxyethyl]-13,21-bis(methoxycarbonylmethylene)-8,8,18,18-tetramet...
参考文献标题:Asymmetric synthesis of the C17-C27 segment of the antineoplastic macrolide bryostatin 1
文献作者:Manaviazar,S.; Lennon,J.A.; Javaid,M.H.; Hobbs,C.J.; Hale,K.J.
参考来源:Tetrahedron Lett 1995,36(8),1359

Cordycepin, 3-dA

虫草素Chemical Name: 3'-Deoxyadenosine
CAS No. 73-03-0
项目整合开发状态: Phase I/II
项目研究机构: National Cancer Institute (Originator), OxiGene (Licensee)
合成路线:A new asymmetric synthesis of stavudine has...
参考文献标题:Asymmetric syntheses of stavudine (d4T) and cordycepin by cycloisomerization of alkynyl alcohols to endocyclic enol ethers
文献作者:Gleason,M.M.; McDonald,F.E.
参考来源:Angew Chem.Int Ed Engl 1995,34(3),350

Spizofurone, AG-629, Maon

螺佐呋酮Chemical Name: 5-Acetylspiro[benzofuran-2(3H),1'-cyclopropan]-3-one
CAS No. 72492-12-7
项目整合开发状态: Withdrawn-1988
项目研究机构: Takeda (Originator)
合成路线:The reaction of methyl-5-acetylsalicyla...
参考文献标题:Spirobenzofuranone compounds,processes for their preparation and their use as medicines
文献作者:Hirosada,S.; Watanabe,M.; Mitsuru,K.; Isuke,I.(Takeda Chemical Industries,Ltd.)
参考来源:CA 1113467; DE 2861651; EP 0003084; ES 476330; ES 8102114; JP 54098752; ZA 7807296

Spirapril, TI-211-950(hydrochloride), Sch-33844(HCl), Setrilan, Sandopril, Renormax

螺普利盐酸螺普利 Chemical Name: (8S)-7-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid 1-ethyl ester
CAS No. 83647-97-6, 94841-17-5 (HCl)
项目整合开发状态: Launc...
参考文献标题:7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids
文献作者:Smith,E.M.; Neustadt,B.R.; Gold,E.H.(Schering Corp.)
参考来源:JP 1989163197; US 4470972

Spiroplatin, TNO-6, NSC-311056

螺铂Chemical Name: (SP-4-2)-(1,1-Cyclohexanedimethanamine-N,N')[sulfato(2-)-O,O']platinum; cis-[1,1-Cyclohexanebis(methylamino)](sulfato)platinum; cis-1,1-Di(aminomethyl)cyclohexane platinum(II) sulfate...
参考文献标题:Spiroplatin
文献作者:Chang,P.
参考来源:Drugs Fut 1984,9(12),907

Cilengitide, NSC-707544, EMD-85189, EMD-121974

西仑吉肽Chemical Name: Cyclo(L-arginyl-glycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl)
CAS No. 188968-51-6, 188969-00-8 (monoHCl), 199807-38-0 (monomethanesulfonate), 199807-35-7 (monotrifluoroaceta...
参考文献标题:Cyclic adhesion inhibitors
文献作者:Jonczyk,A.; Goodman,S.; Diefenbach,B.; Sutter,A.; H鰈zmann,G.; Kessler,H.; Dechantsreiter,M.(Merck Patent GmbH)
参考来源:DE 19534177; EP 0770622; JP 1997132593; US 6001961

Sitaxsentan sodium, TBC-11251, Thelin

西他塞坦钠西他生坦 Chemical Name: N-(4-Chloro-3-methylisoxazol-5-yl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]thiophene-3-sulfonamide sodium salt
CAS No. 210421-74-2, 184036-34-8 (free acid), 215501-46-5...
参考文献标题:Thienyl-,furyl-,pyrrolyl- and biphenylsulfonamides and derivs.thereof that modulate the activity of endothelin
文献作者:Chan,M.F.; Raju,B.G.; Kois,A.; Verner,E.J.; Wu,C.; Castillo,R.S.; Yalamoori,V.; Balaji,V.N.(Texas Biotechnology Corp.)
参考来源:EP 0819125; JP 1999507015; WO 9631492

Spifloxacin hydrate, Sitafloxacin hydrate, DU-6859a, DU-6859(anhydrous), Gracevit

西他沙星水合物西他沙星西他沙星Chemical Name: (-)-7-[7(S)-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-cis-2-fluorocyclopropyl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid sesquihydrate
CAS No....
参考文献标题:Optically active pyridone carboxylic acid derivs
文献作者:Hayakawa,I.; Kimura,Y.(Daiichi Pharmaceutical Co.,Ltd.)
参考来源:AU 8933702; EP 0341493; JP 1990231475; JP 1995300416; JP 1999124367; JP 1999124380; US 5587386; US 5767127

Cilansetron, KC-9946, Calmactin

西兰司琼(10R)-10-[(2-甲基-1H-吡唑-1-基)甲基]-5,6,9,10-四氢-4H-吡啶[3,2,1-jk]碳铉-11(8H)-一盐酸水合物Chemical Name: (-)-(R)-10-(2-Methyl-1H-imidazol-1-ylmethyl)-4,5,6,8,9,10-hexahydro-11H-pyrido[3,2,1-jk]carbazol-11-one
C...
参考文献标题:New anellated indole derivs.
文献作者:Haeck,H.H.; Hamminga,D.; Van Wijngaarden,I.; Wouters,W.(Duphar International Research BV)
参考来源:AU 8818414; EP 0297651; JP 1989022870; US 4939136

Cicaprost, ZK-96480

西卡前列素Chemical Name: [2-[(2E,3aS,4S,5R,6aS)-Octahydro-5-hydroxy-4-[(3S,4S)-3-hydroxy-4-methyl-1,6-nonadiinyl]-2-pentalenylidene]ethoxy]acetic acid
CAS No. 95722-07-9
项目整合开发状态: Phase II
项目研究机构:...
参考文献标题:Novel carbacyclins,processes for their preparation and their use as medicinal agents
文献作者:Haberey,M.; Rad點hel,B.; Schillinger,E.; Skuballa,W.; St黵zebecher,C.-S.; Town,M.H.; Vorbr黦gen,H.(Schering AG)
参考来源:EP 0119949; US 5013758