项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Tracazolate, ICI-136753

西卡唑酯Chemical Name: 4-(Butylamino)-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester
CAS No. 41094-88-6
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The cyclization of 1-e...
参考文献标题:
文献作者:Hans,H.; Theodor,D.
参考来源:BE 787249; CA 997350; CA 997352; CH 549590; CH 553798; CH 553800; DE 2237765; FR 2150737; GB 1402172; JP 7326796; NL 7210701; US 3833594; US 3856799; US 3925388; ZA 7204745

Cilastatin sodium, Cilastatino, MK-791, L-642957

西司他丁钠西司他丁 Chemical Name: [R-[R*,S*(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic acid monosodium salt
CAS No. 81129-83-1, 82009-34-5 (free acid) 参考文献标题:2-(Cyclopropanecarboxamido)-alkenoic acids,their esters and salts,and antibacterial compositions comprising the same a thiennamycin-type compound
文献作者:Graham,D.W.; Rogers,E.F.; Kahan,F.M.(Merck & Co.,Inc.)
参考来源:EP 0048301

Cidofovir, GS-0504, GS-504, HPMPC, Forvade, Vistide

西多福韦西多福韦 (S)-(((1-(4-氨基-2-氧代嘧啶-1(2H)-基)-3-羟基丙烷-2-基)氧基)甲基)膦酸钠(1:x)Chemical Name: (S)-1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine; [(S)-2-[4-Amino-2-oxo-1(2H)-pyrimidinyl]-1-(hydroxymethyl)ethoxyme...
参考文献标题:N-Phosphonylmethoxyalkyl derivs.of pyrimidine and urine bases,methods for their preparation and pharmaceutical compsns.therefrom with antiviral activity
文献作者:Holy,A.; Rosenberg,I.; De Clercq,E.(Czech Academy of Sciences; Rega Institute for Medical Research)
参考来源:EP 0253412; JP 1988045289; US 5142051; US 5869467

Sinefungin, Compound-57926, A-9145, Antibiotic 32232RP

西奈芬净Chemical Name: 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-beta-D-ribo-decofuranuroic acid
CAS No. 58944-73-3
项目整合开发状态: Preclinical
项目研究机构: Lilly (Originator)
合成路线:A to...
参考文献标题:Total synthesis of (+)-sinefungin
文献作者:Ghosh,A.K.; Liu,W.M.
参考来源:J Org Chem 1996,61(18),6175

Seocalcitol, EB-1089

西奥骨化醇Chemical Name: 20(R)-[5-Ethyl-5-hydroxyhepta-1(E),3(E)-dienyl]-1(S),3(R)-dihydroxy-9,10-secopregna-5(Z),7(E),10(19)-triene; 1alpha,25-Dihydroxy-26,27-dimethyl-24a-homo-22,23,24,24a-tetradehydrovi...
参考文献标题:Novel vitamin D analogues
文献作者:Binderup,E.T.; Calverley,M.J.(Leo Pharmaceutical Products Ltd.A/S)
参考来源:EP 0482100; JP 1992506965; US 5190935; WO 9100855

Cilnidipine, Cinaldipine, FRC-8653, Cinalong, Atelec, Siscard

西尼地平Chemical Name: (?-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 2-methoxyethyl (E)-3-phenyl-2-propenyl diester
CAS No. 132203-70-4, 102106-21-8 (undefined stereoch.)<...
参考文献标题:1,4-Dihydropyridine derivs.,methods for their production and pharmaceutical compsns.comprising the same
文献作者:Kutsuma,T.; Ikawa,H.; Sato,Y.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:EP 0161877; JP 1985233058; JP 1986007255; JP 1989025758; US 4672068

Cinitapride hygrogen tartrate, LAS-17177, Blaston, Cidine

西尼必利 4-氨基-N-[1-(3-环己生-1-甲基)-4-哌啶基]-2-乙氧基-5-硝基苯甲酰胺(2E)-2-丁烯二酯(1:1) Chemical Name: 4-Amino-N-[1-(3-cyclohexen-1-ylmethyl)-4-piperidinyl]-2-ethoxy-5-nitrobenzamide hydrogen L-(+)-tartrate
CAS No. 6656...
参考文献标题:Piperidine cpds
文献作者:Boix Iglesias,J.; Prieto Soto,J.; Vega Nogerola,A.; Moragues Mauri,J.
参考来源:GB 1574419

Sipatrigine, 619C89, 619C, BW-619C89

西帕曲近Chemical Name: 4-Amino-2-(4-methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidine; 2-(4-Methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidine-4-amine
CAS No. 130800-90-7, 130801-14-8 (m...
参考文献标题:Pharmacologically active CNS cpds.
文献作者:Miller,A.A.; Nobbs,M.S.; Hyde,R.M.; Leach,M.J.(Glaxo Wellcome plc)
参考来源:AU 8945964; EP 0372934; EP 0713703; EP 0715851; EP 0727212; EP 0727213; EP 0727214; JP 1990202876; US 5587380; US 5597828; US 5635507; US 5684005

Cimetropium bromide, DA-3177, Alginor

西托溴铵Chemical Name: [7(S)-(1alpha,2beta,4beta,5alpha,7beta)]-9-(Cyclopropylmethyl)-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0(2,4)]nonane bromide
CAS No. 51598-60-8<...
参考文献标题:DA-3177
文献作者:de Angelis,L.; Castar,J.
参考来源:Drugs Fut 1978,3(7),509

Cirazoline, LD-3098

西拉唑啉Chemical Name: 2-[(o-Cyclopropylphenoxy)methyl]-2-imidazoline; 2-[(2-Cyclopropylphenoxy)methyl]-4,5-dihydro-1H-imidazole
CAS No. 59939-16-1
项目整合开发状态: Preclinical
项目研究机构: Sanofi-Aventis (O...
参考文献标题:2-(2'-Cyclopropylphenoxymethyl)-2-imidazoline and pharmaceutically acceptable salts thereof
文献作者:Najer,H.; Giudidelli,J.F.(Sanofi-Synthabo)
参考来源:DE 2234714; ES 404927; FR 2145423; GB 1386355; US 3803130