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项目整合精选>>>Cilnidipine, Cinaldipine, FRC-8653, Cinalong, Atelec, Siscard
Cilnidipine, Cinaldipine, FRC-8653, Cinalong, Atelec, Siscard
西尼地平Chemical Name: (?-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 2-methoxyethyl (E)-3-phenyl-2-propenyl diester
CAS No. 132203-70-4, 102106-21-8 (undefined stereoch.)
项目整合开发状态: Launched-1995
项目研究机构: UCB Japan (Originator), Nippon Boehringer Ingelheim (Not Determined), Ajinomoto (Licensee), Roussel Morishita (Licensee), Mochida (Distributor)
合成路线:By cyclization of 2-(3-nitrobenzylidene)acetocetic acid cinnamyl ester (I) with 2-aminocrotonic acid 2-methoxyethyl ester (II) by heating at 120 C.
📌 参考资料/链接：
参考文献标题:1,4-Dihydropyridine derivs.,methods for their production and pharmaceutical compsns.comprising the same
文献作者:Kutsuma,T.; Ikawa,H.; Sato,Y.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:EP 0161877; JP 1985233058; JP 1986007255; JP 1989025758; US 4672068
📄 详细内容
合成路线:By cyclization of 2-(3-nitrobenzylidene)acetocetic acid cinnamyl ester (I) with 2-aminocrotonic acid 2-methoxyethyl ester (II) by heating at 120 C.
参考文献标题:Cinildipine
文献作者:Mealy,N.; Castar,J.
参考来源:Drugs Fut 1996,21(3),249
产品链接: CAS No. 132203-70-4››