Seocalcitol, EB-1089

西奥骨化醇Chemical Name: 20(R)-[5-Ethyl-5-hydroxyhepta-1(E),3(E)-dienyl]-1(S),3(R)-dihydroxy-9,10-secopregna-5(Z),7(E),10(19)-triene; 1alpha,25-Dihydroxy-26,27-dimethyl-24a-homo-22,23,24,24a-tetradehydrovitamin D3; (5Z,7E,22E,24E)-24a,26a,27a-Trihomo-9,10-secocholesta-5,7,10(19),22,24-pentaene-1alpha,3beta,25-triol
CAS No. 134404-52-7
项目整合开发状态: Phase III
项目研究机构: Leo (Originator)
合成路线:Wittig reaction of the vitamin D-derived aldehyde (I) with 3-(methoxycarbonyl)-2-propenyl-1-idene triphenylphosphorane (II) produced the dienoate ester (III).Subsequent addition of ethyllithium to the ester group of (III) furnished the tertiary alcohol (IV).Photochemical isomerization of the 5-6 double bond of (IV) gave rise to the (5Z)-isomer (V),which was finally desilylated using tetrabutylammonium fluoride in THF.