Spiroplatin, TNO-6, NSC-311056
螺铂Chemical Name: (SP-4-2)-(1,1-Cyclohexanedimethanamine-N,N')[sulfato(2-)-O,O']platinum; cis-[1,1-Cyclohexanebis(methylamino)](sulfato)platinum; cis-1,1-Di(aminomethyl)cyclohexane platinum(II) sulfate
CAS No. 74790-08-2
项目整合开发状态: Phase II
项目研究机构: Nederlandse Centrale Org. TNO (Originator)
合成路线:The reaction of 1,1-di(aminomethyl)cyclohexane (I) with potassium iodide and potassium tetrachloroplatinate in water gives cis-diiodo-1,1-di(aminomethyl)cyclohexane platinum (II),which is treated with Ag2SO4.
📌 参考资料/链接：
参考文献标题:Spiroplatin
文献作者:Chang,P.
参考来源:Drugs Fut 1984,9(12),907
📄 详细内容
合成路线:The reaction of 1,1-di(aminomethyl)cyclohexane (I) with potassium iodide and potassium tetrachloroplatinate in water gives cis-diiodo-1,1-di(aminomethyl)cyclohexane platinum (II),which is treated with Ag2SO4.
参考文献标题:Platinum-diamine complexes,a method for the preparation of a medicine using such a platinum-diamine complex for the treatment of malignant tumor in mice
文献作者:Berg,J.; Bulten,E.J.; Verbeek,F.
参考来源:DE 2927056; FR 2430406; FR 2511685; GB 2024823; US 4410544
产品链接: CAS No. 74790-08-2››