Mofezolac, N-22, Disopain
莫非佐酸Chemical Name: 3,4-Bis(4-methoxyphenyl)-5-isoxazoleacetic acid; 3,4-Di-(p-methoxyphenyl)isoxazole-5-acetic acid
CAS No. 78967-07-4
项目整合开发状态: Launched-1994
项目研究机构: Mitsubishi Pharma (Originator), Taiho (Originator)
合成路线:The reaction of desoxyanisoin (I) with hydroxylamine in methanol gives the corresponding oxime (I),which is cyclized with ethyl acetate (III) by means of n-butyllithium in THF yielding 3,4-di(4-methoxyphenyl)-5-methylisoxazole (IV).Finally,this compound is condensed with CO2 by means of n-butyllithium in THF.
📌 参考资料/链接：
参考文献标题:3,4-Diaryl-5-acetic acid cpds.,process for prepar
文献作者:Micetich,R.G.; Shaw,C.-C.; Rastogi,R.B.(CDC Life Sciences Inc.)
参考来源:EP 0026928; US 4327222
📄 详细内容
合成路线:The reaction of desoxyanisoin (I) with hydroxylamine in methanol gives the corresponding oxime (I),which is cyclized with ethyl acetate (III) by means of n-butyllithium in THF yielding 3,4-di(4-methoxyphenyl)-5-methylisoxazole (IV).Finally,this compound is condensed with CO2 by means of n-butyllithium in THF.
参考文献标题:N-22
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(12),1050
产品链接: CAS No. 78967-07-4››