项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Balsalazide disodium, BX-661A, Balzide, Colazal, Colazide

巴柳氮巴柳氮二钠 Chemical Name: (E)-5-[[4-[(2-Carboxyethyl)carbamoyl]phenyl]azo]salicylic acid disodium salt; (E)-5-[[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]azo]-2-hydroxybenzoic acid disodium salt
CAS...
参考文献标题:2-Hydroxy-5-phenylazobenzoic acid derivatives and method of treating ulcerative colitis therewith
文献作者:Chan,R.P.K.(Biorex Laboratories Ltd.)
参考来源:GB 2080796

Balofloxacin dihydrate, Q-35, Baloxin, Neuroquinoron

巴洛沙星Chemical Name: (?-1-Cyclopropyl-6-fluoro-8-methoxy-7-[3-(methylamino)piperidin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dihydrate
CAS No. 127294-70-6 (anhydrous)
项目整合开发状态: Phase II...
参考文献标题:Novel quinolinecarboxylic acid derivatives
文献作者:Nagano,H.; Yokota,T.; Katoh,Y.(Chugai Seiyaku Co.,Ltd.)
参考来源:EP 0342675; JP 91095177

Batimastat, ISV-615, ISV-120, BB-94

巴马司他巴马司他单钠盐 Chemical Name: 3(S)-(N-Hydroxycarbamoyl)-2(R)-isobutyl-4-(2-thienylthio)butyryl-L-phenylalanine methylamide; (2S,3R)-5-Methyl-3-[[(alphaS)-alpha-(methylcarbamoyl)phenethyl]carbamoyl]-2-[(...
参考文献标题:Hydroxamic acid based collagenase inhibitors
文献作者:Campion,C.; Davidson,A.H.; Dickens,J.P.; Crimmin,M.J.(British Biotech plc)
参考来源:US 5240958; US 5310763; WO 9005719

Brequinar sodium, NSC-368390, DuP-785

布列奎钠布喹那 Chemical Name: 2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methylquinoline-4-carboxylic acid sodium salt
CAS No. 96201-88-6, 96187-53-0 (free acid)
项目整合开发状态: Phase II
项目研究机构: Bristol...
参考文献标题:Phenylquinolinecarboxylic acids and derivatives as antitumor agents
文献作者:Hesson,D.P.(DuPont Pharmaceuticals Co.)
参考来源:AU 8430852; EP 0133244; JP 8542367; US 4680299

Blonanserin, AD-5423, Lonasen

布南色林Chemical Name: 2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
CAS No. 132810-10-7
项目整合开发状态: Phase III
项目研究机构: Dainippon Pharmaceutical (Originator...
参考文献标题:2-(1-Piperazinyl)-4-phenylcycloalkanopyridine derivs.,processes for the production thereof,and pharmaceutical compsn.containing the same
文献作者:Hino,K.; Kai,N.; Sakamoto,M.; Kon,T.; Oka,M.; Furakawa,K.; Ochi,Y.(Dainippon Pharmaceutical Co.,Ltd.)
参考来源:EP 0385237; JP 1991007257; JP 1994041079; US 5021421

Budesonide, S-1320, Pulmaxan, Pulmicort, Rhinocort, Entocort, Budenofalk, Preferid, Pulmicort turbuhaler, Budiair, Pulmaxan turbohaler, Pulmicort Topinasal, Pulmicort Respules, Inflammide, Giona Easyhaler, Miflonide, Rhinocort Aqua

布地奈德Chemical Name: 16alpha,17alpha-(22R,S)-Propylmethylenedioxypregna-1,4-diene-11beta,21-diol-3,20-dione; (11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
CAS...
参考文献标题:Budesonide
文献作者:Dharma,A.P.
参考来源:Drugs Fut 1980,5(4),179

Butopamine, LY-131126

布托巴胺Chemical Name: 4-[3(R)-[2(R)-Hydroxy-2-(4-hydroxyphenyl)ethylamino]butyl]phenol
CAS No. 66734-12-1
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The benzylation of methyl 2-(4-hydroxyphen...
参考文献标题:
文献作者:Mills,J.; et al.
参考来源:BE 877391; EP 7205; FR 2430408; GB 2029407; JP 8009098

Butocrolol, P-18

布托洛尔Chemical Name: 9-[3-(tert-Butylamino)-2-hydroxypropoxy]-4-hydroxy-7-methyl-5H-furo[3,2-g]-1-benzopyran-5-one
CAS No. 55165-22-5
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The demethylation...
参考文献标题:
文献作者:
参考来源:FR 2232311

Bulaquine, 80/53, CDRI-80/53

布拉喹Chemical Name: N1-(3-Acetyl-4,5-dihydrofuran-2-yl)-N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine; 1-[4,5-Dihydro-2-[4-(6-methoxyquinolin-8-ylamino)pentylamino]furan-3-yl]ethanone
CAS No. 79781-...
参考文献标题:Use of primaquine derivs.for the treatment of malaria
文献作者:Bhaduri,A.P.; Singh,S.; Singh,S.K.; Asthana,O.P.; Pratap,R.; Gupta,R.C.; Srivastava,S.; Thapliyal,H.P.; Puri,S.K.; Dutta,G.P.; Dwivedi,A.K.; Srivastava,P.; Pandey,V.C.; Srivastava,J.S.(Council of Scientific and Industrial Research)
参考来源:EP 1055427

Butikacin, UK-18892

布替卡星Chemical Name: (1S,2S,3R,4S,6R)-4-Amino-3-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-6-[4-amino-2(S)-hydroxybutylamino]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
CAS No. 5973...
参考文献标题:
文献作者:Kawaguchi,H.; Naito,T.
参考来源:AU 316750; CA 966831; DE 2234315; FR 2145649; GB 1401221; US 3781268; ZA 7204736