Balsalazide disodium, BX-661A, Balzide, Colazal, Colazide
巴柳氮 巴柳氮二钠 Chemical Name: (E)-5-[[4-[(2-Carboxyethyl)carbamoyl]phenyl]azo]salicylic acid disodium salt; (E)-5-[[4-[[(2-Carboxyethyl)amino]carbonyl]phenyl]azo]-2-hydroxybenzoic acid disodium salt
CAS No. 80573-04-2 (free acid), 150399-21-6 (hydrate)
项目整合开发状态: Launched-1997
项目研究机构: Biorex Laboratories (Originator), Malesci (Not Determined), Chong Kun Dang Pharm. (Licensee), Menarini (Licensee), Salix (Licensee), Shire Pharmaceuticals (Licensee)
合成路线:The diazotation of 3-(4-aminobenzoylamino)propionic acid (I) with NaNO2 and HCl gives the corresponding diazonium salt (II),which is then condensed with salicylic acid.
📌 参考资料/链接：
参考文献标题:2-Hydroxy-5-phenylazobenzoic acid derivatives and method of treating ulcerative colitis therewith
文献作者:Chan,R.P.K.(Biorex Laboratories Ltd.)
参考来源:GB 2080796
📄 详细内容
合成路线:The diazotation of 3-(4-aminobenzoylamino)propionic acid (I) with NaNO2 and HCl gives the corresponding diazonium salt (II),which is then condensed with salicylic acid.
参考文献标题:Balsalazide and Ipsalazide
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(5),313
产品链接: CAS No. 80573-04-2›› 产品链接: CAS No.150399-21-6››