Balofloxacin dihydrate, Q-35, Baloxin, Neuroquinoron
巴洛沙星Chemical Name: (?-1-Cyclopropyl-6-fluoro-8-methoxy-7-[3-(methylamino)piperidin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid dihydrate
CAS No. 127294-70-6 (anhydrous)
项目整合开发状态: Phase III
项目研究机构: Chugai (Originator), Choongwae (Licensee), Novartis (Licensee)
合成路线:By reaction of 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (I) with 3-(methylamino)piperidine (II) by means of triethylamine in refluxing acetonitrile.
📌 参考资料/链接：
参考文献标题:Novel quinolinecarboxylic acid derivatives
文献作者:Nagano,H.; Yokota,T.; Katoh,Y.(Chugai Seiyaku Co.,Ltd.)
参考来源:EP 0342675; JP 91095177
📄 详细内容
合成路线:By reaction of 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (I) with 3-(methylamino)piperidine (II) by means of triethylamine in refluxing acetonitrile.
参考文献标题:Q-35
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1992,17(5),382
产品链接: CAS No. 127294-70-6››