项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Palatrigine, BW A256C

帕拉曲近Chemical Name: 5(3)-Amino-6-(2,3-dichlorophenyl)-2,3(2,5)-dihydro-3(5)-imino-2-isopropyl-1,2,4-triazine
CAS No. 98410-36-7, 98410-66-3 (monoHI), 98410-37-8 (monomethanesulfonate)
项目整合开发状态: P...
参考文献标题:1,2,4-Triazines
文献作者:Miller,A.A.; Allan,G.; Sawyer,D.A.(Glaxo Wellcome plc)
参考来源:EP 0142306; ES 8606304; JP 1985109577; US 4649139

Peramivir, RWJ-270201, BCX-1812

帕拉米韦三水环戊烷甲酸,3-[(1S)-1-(乙酰氨基)-2-乙基丁基]-4-[(氨基亚氨基)氨基]-2-羟基-,(1R,2R,3S,4S)-rel-Chemical Name: (1S,2S,3R,4R)-3-[1(S)-(Acetylamino)-2-ethylbutyl]-4-[[amino(imino)methyl]amino]-2-hydroxycyclopentanecarboxyli...
参考文献标题:Substd.cyclopentane and cyclopentene cpds.useful as neuraminidase inhibitors
文献作者:Montgomery,J.A.; Babu,Y.S.; Chand,P.(BioCryst Pharmaceuticals,Inc.)
参考来源:WO 9933781

Parsalmide

帕沙米特Chemical Name: 5-Amino-N-butyl-2-(2-propynyloxy)benzamide
CAS No. 30653-83-9
项目整合开发状态: Not Determined
项目研究机构:
合成路线:The reaction of 5-acetamino-O-acetylsalicylic acid (I) with SOCl2 gi...
参考文献标题:Pr閜aration et activit?th閞apeutique de quelques alcoxy-2-acetamino-5-benzamines
文献作者:Pedrazzoli,A.; et al.
参考来源:Chim Ther 1968,3200-209

Palonidipine hydrochloride, TC-81

帕洛地平帕洛地平盐酸盐Chemical Name: (?-3-(N-Benzyl-N-methylamino)-2,2-dimethylpropyl methyl 2,6-dimethyl-4-(2-fluoro-5-nitrophenyl)-1,4-di-hydropyridine-3,5-dicarboxylate hydrochloride; (?-3-(N-Benzyl-N-methyla...
参考文献标题:1,4-Dihydropyridine derivs.,process for production thereof and pharmaceutical use thereof
文献作者:Yamaguchi,H.; Odamiya,Y.; Kanno,H.; Sunakawa,K.(Teijin Ltd.)
参考来源:EP 0128010; JP 1984222474; JP 1984227859; JP 1985104065; US 4578395

Pazufloxacin, T-3761, GM-1171, Pasil

帕珠沙星帕珠沙星单盐酸盐甲磺酸帕珠沙星Chemical Name: (S)-(-)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid
CAS No. 127045-41-4, 127046-45-1 (mono...
参考文献标题:Pyridonecarboxylic acid derivs.and their salts,process for their preparation as well as antibacterial agent containing them
文献作者:Narita,H.; Todo,Y.; Nitta,J.; Takagi,H.; Iino,F.; Miyajima,M.; Fukuoka,Y.; Saikawa,I.(Toyama Chemical Co.,Ltd.)
参考来源:CH 680793; DE 3913245; JP 1993043464; US 4990508

Parecoxib sodium, SC-69124A, Rayzon, Xapit, Dynastat

帕瑞昔布钠帕瑞昔布Chemical Name: N-[4-(5-Methyl-3-phenylisoxazol-4-yl)phenylsulfonyl]propionamide sodium salt
CAS No. 198470-85-8, 197502-82-2 (deleted CAS), 198470-84-7 (free acid)
项目整合开发状态: Launched-20...
参考文献标题:Substd.benzenesulfonamide derivs.as prodrugs of COX-2 inhibitors
文献作者:Talley,J.J.; Malecha,J.W.; Bertenshaw,S.; Graneto,M.J.; Carter,J.S.; Li,J.; Nagarajan,S.; Brown,D.L.; Rogier,D.J.Jr.; Penning,T.D.; Khanna,I.K.; Xu,X.; Weier,R.M.(Pharmacia Corp.)
参考来源:EP 0892791; JP 2000509029; US 5932598; WO 9738986

Pazinaclone, A-77000, DN-2327

帕秦克隆Chemical Name: (?-2-(7-Chloro-1,8-naphthyridin-2-yl)-3-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]isoindolin-1-one; (?-8-[[2-(7-Chloro-1,8-naphthyridin-2-yl)-2,3-dihydro-3-oxo-1H-isoindol...
参考文献标题:Isoindolinone derivs.,production and use thereof
文献作者:Goto,G.; Saji,Y.(Takeda Chemical Industries,Ltd.)
参考来源:EP 0174858; JP 1986069773; JP 1990262578; JP 1992364180; US 4778801

Paricalcitol, Paracalcin, Compound-49510, ABT-358, Zemplar

帕立骨化醇Chemical Name: 1,25-Dihydroxy-19-norvitamin D2; (7E,22E)-19-Nor-9,10-secoergosta-5,7,22-triene-1alpha,3beta,25-triol
CAS No. 131918-61-1
项目整合开发状态: Launched-1998
项目研究机构: Abbott (Originato...
参考文献标题:19-Nor vitamin D cpds
文献作者:DeLuca,H.F.; Schnoes,H.K.; Perlman,K.L.; Sicinski,R.R.; Prahl,J.M.(Wisconsin Alumni Research Foundation)
参考来源:EP 0387077; JP 1991505330; US 5246925; WO 9010620

Disodium pamidronate, Pamidronate sodium, CGP-23339A, AHPrBP, CGP-23339AE(pentahydrate), APD(free acid), IG-7913, Aredia, Aminomux

帕米膦酸二钠帕米膦酸帕米膦酸二钠Chemical Name: 3-Amino-1-hydroxypropylidene-1,1-diphosphonate disodium salt; 3-Amino-1-hydroxypropylidene-1,1-biphosphonic acid disodium salt
CAS No. 57248-88-1, 40391-99-9 (free ...
参考文献标题:Arylamine derivs.and their use as anti-telomerase agent
文献作者:Mailliet,P.; Riou,J.-F.; Laoui,A.; Mergny,J.-L.; Lavelle,F.; Petitgenet,O.(Aventis Pharma SA)
参考来源:FR 2801588; WO 0140218

Paroxetine, NNC-20-7051, BRL-29060, FG-7051

帕罗西汀Chemical Name: (-)-(3S,4R)-3-(1,3-Benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine
CAS No. 61869-08-7
项目整合开发状态: Launched-1991
项目研究机构: Ferrosan A/S (Originator), GlaxoSmithKline (Li...
参考文献标题:Piperidine derivs.,their preparation and their use as medicaments
文献作者:Lynch,I.R.; Richardson,J.E.; Buxton,P.C.; Curzons,A.D.; Wood-Kaezmar,M.W.; Barnes,R.D.(Ferrosan A/S; SmithKline Beecham plc)
参考来源:EP 0223403; JP 1987129280; US 4721723