Palatrigine, BW A256C
帕拉曲近Chemical Name: 5(3)-Amino-6-(2,3-dichlorophenyl)-2,3(2,5)-dihydro-3(5)-imino-2-isopropyl-1,2,4-triazine
CAS No. 98410-36-7, 98410-66-3 (monoHI), 98410-37-8 (monomethanesulfonate)
项目整合开发状态: Phase II
项目研究机构: GlaxoSmithKline (Originator)
合成路线:3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) (I) is alkylated with 2-iodopropane in refluxing pentan-2-one.The free base,obtained following treatment of the hydroiodide with methanolic sodium hydroxide,is converted to the title compound with methanolic hydrogen chloride.
📌 参考资料/链接：
参考文献标题:1,2,4-Triazines
文献作者:Miller,A.A.; Allan,G.; Sawyer,D.A.(Glaxo Wellcome plc)
参考来源:EP 0142306; ES 8606304; JP 1985109577; US 4649139
📄 详细内容
合成路线:3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) (I) is alkylated with 2-iodopropane in refluxing pentan-2-one.The free base,obtained following treatment of the hydroiodide with methanolic sodium hydroxide,is converted to the title compound with methanolic hydrogen chloride.
参考文献标题:BW-A256C
文献作者:Donoghue,S.; Sawyer,D.; Allan,G.
参考来源:Drugs Fut 1987,12(7),621
产品链接: CAS No. 98410-36-7››