合成路线:The reaction of 5-acetamino-O-acetylsalicylic acid (I) with SOCl2 gives the corresponding acyl chloride (II) which is condensed with N-butylamine (III) and hydrolyzed with NaOH yielding 5-acetamino-N-butylsalicylamide (IV).The condensation of (IV) with propargyl bromide (V) by means of sodium isopropylate in refluxing isopropanol affords 2-propargyloxy-5-acetamino-N-butylbenzamide (VI) (1),which is finally hydrolyzed with hot 4N H2SO4 (2).
参考文献标题:Sintesi ed attivit?farmacologiche preliminari di una serie di 2-alchilossi-5-amino-alchil-benz-amidi
文献作者:Pedrazzoli,A.; et al.
参考来源:Boll Chim Farm 1976,115(2a),125-134
合成路线:The reaction of 5-acetamino-O-acetylsalicylic acid (I) with SOCl2 gives the corresponding acyl chloride (II) which is condensed with N-butylamine (III) and hydrolyzed with NaOH yielding 5-acetamino-N-butylsalicylamide (IV).The condensation of (IV) with propargyl bromide (V) by means of sodium isopropylate in refluxing isopropanol affords 2-propargyloxy-5-acetamino-N-butylbenzamide (VI) (1),which is finally hydrolyzed with hot 4N H2SO4 (2).
参考文献标题:Parasalmide
文献作者:Castar,J.; De Angelis,L.
参考来源:Drugs Fut 1977,2(1),55
产品链接: CAS No. 30653-83-9››