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项目整合精选>>>Disodium pamidronate, Pamidronate sodium, CGP-23339A, AHPrBP, CGP-23339AE(pentahydrate), APD(free acid), IG-7913, Aredia, Aminomux
Disodium pamidronate, Pamidronate sodium, CGP-23339A, AHPrBP, CGP-23339AE(pentahydrate), APD(free acid), IG-7913, Aredia, Aminomux
帕米膦酸二钠 帕米膦酸 帕米膦酸二钠Chemical Name: 3-Amino-1-hydroxypropylidene-1,1-diphosphonate disodium salt; 3-Amino-1-hydroxypropylidene-1,1-biphosphonic acid disodium salt
CAS No. 57248-88-1, 40391-99-9 (free acid), 109552-15-0 (pentahydrate)
项目整合开发状态: Launched-1987
项目研究机构: Gador (Originator), Henkel (Originator), Nippon Kayaku (Not Determined), Nippon Kayaku (Marketer), Novartis (Licensee)
合成路线:By reaction of beta-alanine (I) with the phosphorous acid and PCl3 in chlorobenzene at 100 C.
合成路线:The condensation of 4,6-dichloro-1,3,5-triazin-2-amine (I) with 6-amino-1-methylquinolinium chloride (II) in refluxing ethanol/water gives the target bis quinolinium chloride.
📌 参考资料/链接：
参考文献标题:Arylamine derivs.and their use as anti-telomerase agent
文献作者:Mailliet,P.; Riou,J.-F.; Laoui,A.; Mergny,J.-L.; Lavelle,F.; Petitgenet,O.(Aventis Pharma SA)
参考来源:FR 2801588; WO 0140218
📄 详细内容
合成路线:By reaction of beta-alanine (I) with the phosphorous acid and PCl3 in chlorobenzene at 100 C.
参考文献标题:1-Hydroxy-3-aminopropan-1,1-diphosphos鋟re und Verfahren zu deren Herstellung
文献作者:Krueger,F.; et al.
参考来源:DE 2130794