项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Ibopamine, SB-7505, Trazyl, Scandine

异波帕胺Chemical Name: Epinine 3,4-O-diisobutyrate; 4-[2-(Methylamino)ethyl]pyrocathecol diisobutyrate
CAS No. 66195-31-1, 66195-32-2 (butanedioate salt), 66195-35-5 (HBr salt)
项目整合开发状态: Launched-19...
参考文献标题:Epinine esters and pharmaceutical compositions thereof
文献作者:Casagrande,C.; Ferrari,G.(Simes SpA)
参考来源:DE 2734678; ES 461399; FR 2360558; GB 1551661; JP 53021130; US 4218470

Isoprofen, UP-517-03

异洛芬Chemical Name: 2-(2-Isopropylindan-5-yl)propionic acid
CAS No. 57144-56-6, 58453-65-9 (sodium salt)
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:The Friedel-Kraft抯 reaction of 2-isopropyl...
参考文献标题:Isoprofen
文献作者:Blancafort,P.; Serradell,M.N.; Castar,J.; Arrigoni,Martelli,E.
参考来源:Drugs Fut 1981,6(8),471

A-62824

异硫唑[5,4-b]喹啉-3,4(2H,9H)-二酮,9-环丙基-6-氟-7-(1-哌哌嗪基)-Chemical Name: 9-Cyclopropyl-6-fluoro-7-(1-piperazinyl)-2,3,4,9-tetrahydroisothiazolo[5,4-b]quinoline-3,4-dione
CAS No. 111279-87-9
项目整合开发状态: Prec...
参考文献标题:Comparison of metabolism and toxicity to the structure of the anticancer agent sulofenur and related sulfonylureas
文献作者:Woodland,J.M.; Todd,G.C.; Bewley,J.R.; Howbert,J.J.; Ehlhardt,W.J.; Grindey,G.B.; Worzalla,J.F.; Toth,J.E.
参考来源:Chem Res Toxicol 1992,5(5),667

13-cis-retinoic acid, Isotretinoin, Ro-43780, Sotret, Amnesteem, Claravis, Roacutan, Roaccutan, Roaccutane, Accutane

异维A酸维甲酸钠盐Chemical Name: 13-cis-Retinoic acid; cis-2-Vitamin A acid
CAS No. 4759-48-2, 22232-80-0 (K salt), 13497-05-7 (Na salt)
项目整合开发状态: Launched-1982
项目研究机构: Roche (Originator), Bertek (Not...
参考文献标题:Isotretinoin
文献作者:Castar,J.; Serradell,M.N.; Hillier,K.; Blancafort,P.
参考来源:Drugs Fut 1979,4(9),651

Fesoterodine, SPM-907

弗斯特罗定Chemical Name: 2-Methylpropionic acid 2-[3-(N,N-diisopropylamino)-1(R)-phenylpropyl]-4-(hydroxymethyl)phenyl ester; Isobutyric acid 2-[3-(diisopropylamino)-1(R)-phenylpropyl]-4-(hydroxymethyl)phe...
参考文献标题:Stable salts of novel derivs.of 3,3-diphenylpropylamines
文献作者:Meese,C.(Schwarz Pharma AG)
参考来源:DE 19955190; JP 2003514018; WO 0135957

A-319492, ABT-492, WQ-3034

德拉沙星Chemical Name: 1-(6-Amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No. 189279-58-1
项目整合开发状态: Phase II
项目研究机构...
参考文献标题:Novel pyridonecarboxylic acid derivs.or their salts and antibacterial agent comprising the same as the active ingredient
文献作者:Yazaki,A.; Niino,Y.; Ohshita,Y.; Hirao,Y.; Amano,H.; Hayashi,N.; Kuramoto,Y.(Wakunaga Pharmaceutical Co.,Ltd.)
参考来源:EP 0911327; EP 0992501; JP 1999322715; JP 2000136191; US 5998436; US 6133284; WO 9711068

Ciclazindol, Wy-23409

心宁美Chemical Name: 10-(m-Chlorophenyl)-2,3,4,10-tetrahydropyrimido[1,2-a]indol-10-ol
CAS No. 37751-39-6
项目整合开发状态: Preclinical
项目研究机构: Wyeth Pharmaceuticals (Originator)
合成路线:The reaction of...
参考文献标题:Process for the preparation of diazepino[1,2-a]indoles
文献作者:White,A.C.; Bell,S.C.(John Wyeth & Brother Ltd.)
参考来源:CH 590286; DE 2417917; FR 2247227; GB 1427066; US 3931226

Enprofylline, D-4028

恩丙茶碱Chemical Name: 3-Propylxanthine; 3,7-Dihydro-3-propyl-1H-purine-2,6-dione
CAS No. 41078-02-8
项目整合开发状态: Phase III
项目研究机构: AstraZeneca (Originator), Merck & Co. (Originator)
合成路线:The rea...
参考文献标题:Method and pharmaceutical preparation for treating chronic obstructive airway disease and cardiac disease,and intermediates for the preparation of therapeutically active xanthine derivs.
文献作者:Kjellin,P.G.; Persson,C.G.A.(Draco L鋕emedel AB)
参考来源:EP 0011609

Entacapone, COM-998, OR-611, Comtess, Comtan

恩他卡朋恩他卡朋Chemical Name: (E)-2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide; (E)-2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide; (E)-alpha-Cyano-N,N-diethyl-3,4-dihydroxy-...
参考文献标题:Novel pharmacologically active cpds.,their process of preparation and compsns.containing them
文献作者:Backstrom,R.J.; Heinola,K.E.; Honkanen,E.J.; Kaakkola,S.K.; Karrisalo,P.J.; Linden,I.-B.Y.; Mannisto,P.T.; Nissinen,E.A.O.; Pohto,P.; Pippuri,A.K.; Pystynen,J.J.(Orion Corporation)
参考来源:AU 8781879; BE 1003279; CH 685436; DE 3740383; FR 2607493; GB 2200109; JP 1988170311; US 4963590; US 5112861

Enprostil, RS-84135, Syngard, Gardrine, Camleed, Gardrin

恩前列素Chemical Name: Methyl 7-[(1R*,2R*,3R*)-3-hydroxy-2-[(E)-(3R*)-3-hydroxy-4-phenoxy-1-butenyl]-5-oxocyclopentyl]-4,5-heptadienoate
CAS No. 73121-56-9
项目整合开发状态: Withdrawn
项目研究机构: Roche Biosc...
参考文献标题:16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives
文献作者:Muchowski,J.M.; Fried,J.H.(Syntex (USA),Inc.)
参考来源:DE 2627910; ES 449162; FR 2315263; US 3985791