Entacapone, COM-998, OR-611, Comtess, Comtan
恩他卡朋恩他卡朋Chemical Name: (E)-2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide; (E)-2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide; (E)-alpha-Cyano-N,N-diethyl-3,4-dihydroxy-5-nitrocinnamamide
CAS No. 130929-57-6, 133180-79-7 ([14C]-labeled), 116314-67-1 (undefined stereoch.)
项目整合开发状态: Launched-1998
项目研究机构: Orion Corp. (Originator), Novartis (Licensee), Bristol-Myers Squibb (Comarketer)
合成路线:Title compound is obtained by reaction of 3,4-dihydroxy-5-nitrobenzaldehyde (I) with N,N-diethyl-2-cyanoacetamide (II) in the presence of piperidine acetate in ethanol.
📌 参考资料/链接：
参考文献标题:Novel pharmacologically active cpds.,their process of preparation and compsns.containing them
文献作者:Backstrom,R.J.; Heinola,K.E.; Honkanen,E.J.; Kaakkola,S.K.; Karrisalo,P.J.; Linden,I.-B.Y.; Mannisto,P.T.; Nissinen,E.A.O.; Pohto,P.; Pippuri,A.K.; Pystynen,J.J.(Orion Corporation)
参考来源:AU 8781879; BE 1003279; CH 685436; DE 3740383; FR 2607493; GB 2200109; JP 1988170311; US 4963590; US 5112861
📄 详细内容
合成路线:Title compound is obtained by reaction of 3,4-dihydroxy-5-nitrobenzaldehyde (I) with N,N-diethyl-2-cyanoacetamide (II) in the presence of piperidine acetate in ethanol.
参考文献标题:Entacapone
文献作者:Castar,J.; Prous,J.; Rabasseda,X.
参考来源:Drugs Fut 1994,19(7),641
产品链接: CAS No. 130929-57-6›› 产品链接: CAS No.116314-67-1››