Brequinar sodium, NSC-368390, DuP-785
布列奎钠 布喹那 Chemical Name: 2-(2'-Fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methylquinoline-4-carboxylic acid sodium salt
CAS No. 96201-88-6, 96187-53-0 (free acid)
项目整合开发状态: Phase II
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:By cyclization of 5-fluoroisatin (I) with 4-(2-fluorophenyl)- propiophenone (II) by means of NaOH in refluxing ethanol - water.
📌 参考资料/链接：
参考文献标题:Phenylquinolinecarboxylic acids and derivatives as antitumor agents
文献作者:Hesson,D.P.(DuPont Pharmaceuticals Co.)
参考来源:AU 8430852; EP 0133244; JP 8542367; US 4680299
📄 详细内容
合成路线:By cyclization of 5-fluoroisatin (I) with 4-(2-fluorophenyl)- propiophenone (II) by means of NaOH in refluxing ethanol - water.
参考文献标题:BREQUINAR SODIUM < Prop INNM >
文献作者:Eastland,G.Jr.; Prous,J.; Castar,J.
参考来源:Drugs Fut 1988,13(1),13
产品链接: CAS No. 96201-88-6›› 产品链接: CAS No.96187-53-0››